Desferal

Land: Australien

Språk: engelska

Källa: Department of Health (Therapeutic Goods Administration)

Aktiva substanser:

Desferrioxamine mesylate

Tillgänglig från:

Novartis Pharmaceuticals Australia Pty Ltd

Klass:

Medicine Registered

Bipacksedel

DESFERAL
®

_desferrioxamine mesylate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Desferal.
The information in this leaflet was
last updated on the date listed on the
final page. More recent information
on the medicine may be available.
YOU SHOULD ENSURE THAT YOU SPEAK
TO YOUR PHARMACIST OR DOCTOR TO
OBTAIN THE MOST UP TO DATE
INFORMATION ON THE MEDICINE. YOU
CAN ALSO DOWNLOAD THE MOST UP TO
DATE LEAFLET FROM
WWW.NOVARTIS.COM.AU
Those updates may contain important
information about the medicine and
its use of which you should be aware.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking this medicine
against the benefits they expect it
will provide.
IF YOU HAVE ANY CONCERNS ABOUT THIS
MEDICINE, ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET.
You may need to read it again.
WHAT DESFERAL IS USED
FOR
Desferal can be used:
•
to treat acute iron poisoning
•
to treat chronic iron overload
Iron can build up in your body if you
take too many iron preparations or if
you have a type of anaemia that
requires a lot of blood transfusions,
such as thalassaemia (also called
Mediterranean anaemia) or sickle cell
anaemia. Desferal is useful in these
cases to reduce iron buildup in the
liver and prevent liver damage.
Desferal belongs to a group of
medicines called metal chelators.
It is an "iron carrier." If you have too
much iron in your body, Desferal
attaches itself to the extra iron and
gets rid of it through the urine and
bowel motions.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY DESFERAL HAS
BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another reason.
Desferal can be used to treat both
adults and children, but children
under 3 years of age may not respond
as well as older people. If you are
unsure whether your child should
have Desferal, your doctor can
provide more

Produktens egenskaper

 
1 

DESFERAL


NAME OF THE DRUG 

Active ingredient: Desferrioxamine mesylate   
Structural formula: 

DESCRIPTION 

Chemical Name: Desferrioxamine
N-[5-(3-[(5-aminopentyl)hydroxycarbamoyl] 
propionamido)--pentyl]-3-([5-(N-hydroxyacetamido) pentyl]-carbamoyl)-propionyl-
hydroxamic acid methane sulphonate  
Empirical formula: C
25
H
48
N
6
O
8
.CH
3
SO
3
H  
CAS number: 138-14-7 
Molecular weight: 656.8 

Desferrioxamine mesylate is a white to cream-coloured,
odourless or almost odourless 
powder with a bitter taste.  Solubility: 1 to 5 (w/v) in water,
insoluble in dehydrated alcohol, 
chloroform and ether.  A 10% solution in
water has a pH of 3.5 to 5.5.  

PHARMACOLOGY 

PHARMACODYNAMICS 
Desferal is a chelating agent
which forms complexes predominantly with ferric iron and to a 
lesser degree with trivalent aluminium ions:
the complex formation constants are 10
31
 and 
10
25
, respectively.
 The affinity of Desferal for divalent ions such as Fe
2+
,
 Cu
2+
,
 Zn
2+
,
 Ca
2+
 is 
substantially lower (complex formation constants 10
14
 or below).  Chelation occurs on a 1:1 
molar basis, so that 1 gram desferrioxamine theoretically can
bind 85 mg ferric iron.   

Desferal chelates free iron and iron bound in ferritin and
haemosiderin to form the complex, 
ferrioxamine. It does not chelate iron in transferrin, haemoglobin
or other iron-containing 
proteins. Iron deposits in the lungs are not removed.  

NH
2
N
N
OH
O
O
H
N
O
N
N
O
OH
O
H
OH
CH
3
CH
3
SO
3
H

2 

Desferal can facilitate excretion of 10 - 50 mg of iron
per day from patients with iron 
overload (a transfusion of 500 mL whole blood adds 250
mg of iron to the body). The 
relationship between Desferal dose and the amount of iron
excreted is non-linear, with 
reducing efficiency at higher doses. 

Desferal reduces patho