Land: Malaysia
Språk: engelska
Källa: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
LAMIVUDINE; ZIDOVUDINE
UNIMED SDN BHD
LAMIVUDINE; ZIDOVUDINE
60Tablet Tablets
Strides Pharma Science Limited
_Consumer Medication Information Leaflet (RiMUP) _ 1 LAMIVUDINE 150MG AND ZIDOVUDINE 300MG TABLETS Lamivudine/Zidovudine (150mg/300mg) WHAT IS IN THIS LEAFLET 1. What Lamivudine 150mg and Zidovudine 300mg Tablets are used for 2. How Lamivudine 150mg and Zidovudine 300mg Tablets work 3. Before you use Lamivudine 150mg and Zidovudine 300mg Tablets 4. How to take Lamivudine 150mg and Zidovudine 300mg Tablets 5. While you are using Lamivudine 150mg and Zidovudine 300mg Tablets 6. Side Effects 7. Storage and Disposal of Lamivudine 150mg and Zidovudine 300mg Tablets 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT LAMIVUDINE 150MG AND ZIDOVUDINE 300MG TABLETS ARE USED FOR AND HOW THEY WORK Lamivudine/Zidovudine tablets are used to treat HIV (human immunodeficiency virus) infection in adults and children above 12 years old. Lamivudine/Zidovudine tablets contains two active ingredients that are used to treat HIV infection: lamivudine and zidovudine. Both of these belong to a group of anti- retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs). HOW LAMIVUDINE 150MG AND ZIDOVUDINE 300MG TABLETS WORK Lamivudine/Zidovudine tablets do not completely cure HIV infection; it reduces the amount of virus in your body, and keeps it at a low level. It also increases the CD4 cell count in your blood. CD4 cells are a type of white blood cells that are important in helping your body to fight infection. Not everyone responds to treatment with Lamivudine/ Zidovudine tablets in the same way. Your doctor will monitor the effectiveness of your treatment. BEFORE YOU USE LAMIVUDINE 150MG AND ZIDOVUDINE 300MG TABLETS _-When you must not take it _ Do not take Lamivudine/Zidovudine Tablets if: • you are allergic to lamivudine or zidovudine, or any of the other ingredients of this medicine • you have a very low red blood cell count (anaemia) or a very low white blood cell count (neutropenia). Check with your doctor if you think any of these apply to you. _-Befo Läs hela dokumentet
ARROW-LZ LAMIVUDINE 150MG & ZIDOVUDINE 300MG TABLETS USP PRODUCT DESCRIPTION White to off - white coloured, oval shaped film-coated tablets, with LZ debossed on one side and breakline on other side. COMPOSITION Each film coated tablet contains Lamivudine150 mg and Zidovudine300 mg. PHARMACOLOGY Lamivudine and zidovudine are potent, selective inhibitors of HIV-1 and HIV-2. Lamivudine has been shown to be highly synergistic with zidovudine, inhibiting the replication of HIV in cell culture. Both active substances are metabolized sequentially by intracellular kinases to 5' - triphosphate (TP). Lamivudine-TP and zidovudine-TP are substrates for and competitive inhibitors of HIV reverse transcriptase. However, their main antiviral activity is through incorporation of the monophosphate form into the viral DNA chain, resulting in chain termination. Lamivudine-TP and Zidovudine-TP show significantly less affinity for host cell DHA polymerases. In vitro, Lamivudine demonstrates low cytotoxicity to peripheral blood lymphocytes, to established lymphocyte and monocyte- macrophage cell lines and to a variety of bone marrow progenitor cells. Lamivudine therefore has a high therapeutic index in vitro. PHARMACODYNAMICS Lamivudine in combination with Zidovudine has been shown to reduce HIV-1 viral load and to increase CD4 cell counts. Clinical endpoint data indicate that Lamivudine in combination with Zidovudine alone or in combination with Zidovudine – containing treatment regimens results in a significant reduction in the risk of disease progression and mortality. Individually, Lamivudine and Zidovudine therapy has resulted in HIV clinical isolates, which show reduced sensitivity in vitro to the nucleoside analogue to which they have been exposed. Evidence from clinical studies show that Lamivudine Plus Zidovudine delays the emergence of Zidovudine- resistance isolates in individuals with no prior antiretroviral therapy. Lamivudine and Zidovudine have been widely used as components of antiretroviral combination therapy with o Läs hela dokumentet