PerioChip

Country: Сингапур

Језик: Енглески

Извор: HSA (Health Sciences Authority)

Активни састојак:

Chlorhexidine digluconate

Доступно од:

APEX PHARMA MARKETING PTE. LTD.

АТЦ код:

A01AB03

Дозирање:

2.50 mg

Фармацеутски облик:

LINER, DENTAL

Састав:

Chlorhexidine digluconate 2.50 mg

Пут администрације:

PERIODONTAL

Тип рецептора:

Prescription Only

Произведен од:

Dexcel Pharma Technologies Ltd

Статус ауторизације:

ACTIVE

Датум одобрења:

2007-05-21

Информативни летак

Because
every tooth
  matters...
PerioChip
® 
is registered trademark of DEXCEL PHARMA TECHNOLOGIES LTD
[chlorhexidine gluconate] 2.5 mg
®
Apex Pharma Marketing Pte Ltd.
12 Harper Road, # 06-00 Sulisam building, Singapore 369677
What is a periodontal disease? 
SRP combined with an adjunct 
therapy has proved to be an effective 
treatment 
Why PerioChip

®

[chlorhexidine gluconate]

2.5
mg 
?
MONTHS
Risk associated with periodontal 
disease
What is PerioChip

®

[chlorhexidine gluconate]

2.5
mg 
?
1 
2
5-6
Following a treatment with PerioChip

®

[chlorhexidine gluconate] 
2.5
mg
7-8
3
4
[chlorhexidine gluconate] 2.5 mg
®
MONTHS
8
Please, notify the next appointment to your dentist & 
your treatment areas: 
Your next appointment is:
Your treatment areas:
Upper
Lower
What is a periodontal disease? 
Date: 
Time: 
Periodontal disease is a serious consequence of a chronic 
infection of the gums that causes destruction of the tissue and 
bone supporting the teeth.
When left untreated, periodontal disease can progress and 
lead to tooth loss.
The primary cause of periodontal disease is an adhesive colorless 
layer, called plaque, which accumulates on the surface of the 
teeth. If the plaque is not removed, it hardens and turns into 
calculus (tartar). When this occurs, the gums may separate 
from the teeth and create pockets.

Healthy Gums
Inflammation
Periodontal 
Pocket
1
[chlorhexidine gluconate] 2.5 mg
®
Treating periodontal disease at an early stage is more beneficial 
than waiting until the disease is more advanced.  Scaling and Root 
Planing (SRP) is a procedure by which tartar is cleaned professionally 
by a dental professional. Using special instruments, the dentist or 
hygienist removes the plaque and bacterial contamination from 
the tooth surface and smoothes the roughness of the�

Карактеристике производа

DESCRIPTION
PerioChip
®
(chlorhexidine gluconate) is a small, orange-brown, rectangular chip
(rounded at one end) for insertion into periodontal pockets. Each
PerioChip contains
2.5 mg of chlorhexidine gluconate in a biodegradable matrix of
hydrolyzed gelatin
(cross-linked with glutaraldehyde).
PerioChip also contains glycerin and purified water.
Chlorhexidine gluconate is an antimicrobial agent. Chemically, it is
designated as 1,1'-
hexamethylenebis [5-(_p_-chlorophenyl)biguanide] di-D-gluconate, and
its molecular
formula is C
22
H
30
Cl
2
N
10
.2C
6
H
12
O
7
. The molecular weight is 897.8. The structural formula
of chlorhexidine gluconate is:
CLINICAL PHARMACOLOGY
MICROBIOLOGY
Chlorhexidine gluconate is active against a broad spectrum of
microbes. The
chlorhexidine molecule, due to its positive charge, reacts with the
microbial cell
surface, destroys the integrity of the cell membrane, penetrates into
the cell,
precipitates the cytoplasm, and the cell dies. Studies with PerioChip
showed reductions
in the numbers of the putative periodontopathic organisms
_Porphyromonas_
_(Bacteroides) gingivalis, Prevotella (Bacteroides) intermedia,
Bacteroides forsythus, _and
_Campylobacter rectus (Wolinella recta)_ after placement of the chip.
No overgrowth of
opportunistic organisms or other adverse changes in the oral microbial
ecosystem
were noted. The relationship of the microbial findings to clinical
outcome has not
been established.
PHARMACOKINETICS
PerioChip releases chlorhexidine _in vitro_ in a biphasic manner,
initially releasing
approximately 40% of the chlorhexidine within the first 24 hours and
then releasing
the remaining chlorhexidine in an almost linear fashion for 7-10 days.
This enzymatic
release rate assay is an experimental collagenase assay that differs
from the Regulatory
Specification's Agar Release Rate Assay. This release profile may be
explained as an
initial burst effect, dependent on diffusion of chlorhexidine from the
chip, followed
by a further release of chlorhexidine as a result of enzymatic