País: Singapur
Idioma: anglès
Font: HSA (Health Sciences Authority)
Chlorhexidine digluconate
APEX PHARMA MARKETING PTE. LTD.
A01AB03
2.50 mg
LINER, DENTAL
Chlorhexidine digluconate 2.50 mg
PERIODONTAL
Prescription Only
Dexcel Pharma Technologies Ltd
ACTIVE
2007-05-21
Because every tooth matters... PerioChip ® is registered trademark of DEXCEL PHARMA TECHNOLOGIES LTD [chlorhexidine gluconate] 2.5 mg ® Apex Pharma Marketing Pte Ltd. 12 Harper Road, # 06-00 Sulisam building, Singapore 369677 What is a periodontal disease? SRP combined with an adjunct therapy has proved to be an effective treatment Why PerioChip ® [chlorhexidine gluconate] 2.5 mg ? MONTHS Risk associated with periodontal disease What is PerioChip ® [chlorhexidine gluconate] 2.5 mg ? 1 2 5-6 Following a treatment with PerioChip ® [chlorhexidine gluconate] 2.5 mg 7-8 3 4 [chlorhexidine gluconate] 2.5 mg ® MONTHS 8 Please, notify the next appointment to your dentist & your treatment areas: Your next appointment is: Your treatment areas: Upper Lower What is a periodontal disease? Date: Time: Periodontal disease is a serious consequence of a chronic infection of the gums that causes destruction of the tissue and bone supporting the teeth. When left untreated, periodontal disease can progress and lead to tooth loss. The primary cause of periodontal disease is an adhesive colorless layer, called plaque, which accumulates on the surface of the teeth. If the plaque is not removed, it hardens and turns into calculus (tartar). When this occurs, the gums may separate from the teeth and create pockets. Healthy Gums Inflammation Periodontal Pocket 1 [chlorhexidine gluconate] 2.5 mg ® Treating periodontal disease at an early stage is more beneficial than waiting until the disease is more advanced. Scaling and Root Planing (SRP) is a procedure by which tartar is cleaned professionally by a dental professional. Using special instruments, the dentist or hygienist removes the plaque and bacterial contamination from the tooth surface and smoothes the roughness of the Llegiu el document complet
DESCRIPTION PerioChip ® (chlorhexidine gluconate) is a small, orange-brown, rectangular chip (rounded at one end) for insertion into periodontal pockets. Each PerioChip contains 2.5 mg of chlorhexidine gluconate in a biodegradable matrix of hydrolyzed gelatin (cross-linked with glutaraldehyde). PerioChip also contains glycerin and purified water. Chlorhexidine gluconate is an antimicrobial agent. Chemically, it is designated as 1,1'- hexamethylenebis [5-(_p_-chlorophenyl)biguanide] di-D-gluconate, and its molecular formula is C 22 H 30 Cl 2 N 10 .2C 6 H 12 O 7 . The molecular weight is 897.8. The structural formula of chlorhexidine gluconate is: CLINICAL PHARMACOLOGY MICROBIOLOGY Chlorhexidine gluconate is active against a broad spectrum of microbes. The chlorhexidine molecule, due to its positive charge, reacts with the microbial cell surface, destroys the integrity of the cell membrane, penetrates into the cell, precipitates the cytoplasm, and the cell dies. Studies with PerioChip showed reductions in the numbers of the putative periodontopathic organisms _Porphyromonas_ _(Bacteroides) gingivalis, Prevotella (Bacteroides) intermedia, Bacteroides forsythus, _and _Campylobacter rectus (Wolinella recta)_ after placement of the chip. No overgrowth of opportunistic organisms or other adverse changes in the oral microbial ecosystem were noted. The relationship of the microbial findings to clinical outcome has not been established. PHARMACOKINETICS PerioChip releases chlorhexidine _in vitro_ in a biphasic manner, initially releasing approximately 40% of the chlorhexidine within the first 24 hours and then releasing the remaining chlorhexidine in an almost linear fashion for 7-10 days. This enzymatic release rate assay is an experimental collagenase assay that differs from the Regulatory Specification's Agar Release Rate Assay. This release profile may be explained as an initial burst effect, dependent on diffusion of chlorhexidine from the chip, followed by a further release of chlorhexidine as a result of enzymatic Llegiu el document complet