Држава: Малезија
Језик: Енглески
Извор: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ACYCLOVIR
XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD
ACYCLOVIR
5gm mcg/mL
XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ AVORAX CREAM 5%W/W Acyclovir (5%w/w) 1 WHAT IS IN THIS LEAFLET: 1. What is Avorax Cream used for 2. How Avorax Cream works 3. Before you use Avorax Cream 4. How to use Avorax Cream 5. While you are using Avorax Cream 6. Side Effects 7. Storage and Disposal of Avorax Cream 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision _ _ WHAT IS AVORAX CREAM USED FOR It is used to treat herpes simplex viral infection (cold sores) on the skin, including initial and recurrent viral infection of lips and genital area. HOW AVORAX CREAM WORKS Avorax contains an active ingredient, Acyclovir. Acyclovir is the anti-viral which inhibits the growth of virus by preventing the spreading of virus in the body. BEFORE YOU USE AVORAX CREAM _When you must not use it _ Do not use Avorax Cream if you are allergic to Acyclovir or any other ingredients in this medicine. are going to use it on the areas with mucous membranes, eg. inside the mouth, eye or vagina. _ _ _Before you start to use it _ Tell your doctor or pharmacist before using Avorax Cream if you: are pregnant or plan to pregnant. are breast-feeding or plan to start breast-feeding. have any other medical problem. _Taking other medicines _ Tell your doctor or pharmacist if you are taking or having recently taken any other medicines. This includes any medicines which you have bought without a prescription. HOW TO USE AVORAX CREAM _How much to use _ Apply continuously for 5-10days over the affected skin areas: every 3-4 hours daily, Or 5 times daily _ _ _When to use it _ Apply as soon as infection is detected. Follow the instruction from your doctor or pharmacist. _How long to use it _ Follow the duration of use that your doctor or pharmacist has suggested. Usually treatment is continued for another 5 days after healing, however, please consult your doctor or pharmacist before prolonged use of this medicine. _If you forget to use it _ Use it as soon as you remember. The Прочитајте комплетан документ
COMPOSITION Contains Acyclovir 5% w/w in a water miscible cream. Chlorocresol 0.10% w/w as preservative. PHARMACODYNAMICS Acyclovir is an antiviral agent which is highly active in vitro against herpes simplex virus (HSV) types I and II and varicella zoster virus. Toxicity to mammalian host cells is low. Acyclovir is phosphorylated after entry into herpes infected cells to the active compound acyclovir triphosphate. The first step in this process is dependent on the presence of the HSV-coded thymidine kinase. Acyclovir triphosphate acts as an inhibitor of, and substrate for, the herpes-specified DNA polymerase, preventing further viral DNA synthesis without affecting normal cellular processes. PHARMACOKINETICS Pharmacology studies have shown only minimal systemic absorption of acyclovir following repeated topical administration of Avorax Cream. INDICATIONS Avorax Cream is indicated in the treatment of herpes simplex infections of the skin, including initial and recurrent labial and genital herpes simplex infections. DOSAGE AND ADMINISTRATION For topical use only. Avorax Cream should be applied every 3 - 4 hours or 5 times daily for 5 - 10 days. Avorax should be applied as soon as infection is detected and treatment must proceed for another 5 days after healing. CONTRAINDICATIONS It is contraindicated in patients with known hypersensitivity to Acyclovir. PRECAUTIONS Acyclovir Cream is not recommended for use on mucous membranes such as in the mouth, eye or vagina. Although no information is yet available on the adverse effects of use during pregnancy and nursing mothers, care should be taken during usage in such conditions. DRUG INTERACTIONS No clinically significant interactions have been identified. INCOMPATIBILITIES None known. USAGE DURING PREGNANCY The use of Avorax Cream should be considered only when the potential benefits outweigh the possibility of unknown risks however the systemic exposure to acyclovir from topical application of Avorax Cream is very low. OVERDOSAGE AND TREATMENT No untoward effects woul Прочитајте комплетан документ