AVORAX CREAM

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ACYCLOVIR

Boleh didapati daripada:

XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD

INN (Nama Antarabangsa):

ACYCLOVIR

Unit dalam pakej:

5gm mcg/mL

Dikeluarkan oleh:

XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
AVORAX CREAM 5%W/W
Acyclovir (5%w/w)
1
WHAT IS IN THIS LEAFLET:
1.
What is Avorax Cream used for
2.
How Avorax Cream works
3.
Before you use Avorax Cream
4.
How to use Avorax Cream
5.
While you are using Avorax Cream
6.
Side Effects
7.
Storage and Disposal of Avorax Cream
8.
Product Description
9.
Manufacturer and Product Registration
Holder
10.
Date of Revision
_ _
WHAT IS AVORAX CREAM USED FOR
It
is
used
to
treat
herpes
simplex
viral
infection (cold sores) on the skin, including
initial and recurrent viral infection of lips
and genital area.
HOW AVORAX CREAM WORKS
Avorax
contains
an
active
ingredient,
Acyclovir.
Acyclovir
is
the
anti-viral
which
inhibits
the
growth
of
virus
by
preventing the spreading of virus in the
body.
BEFORE YOU USE AVORAX CREAM
_When you must not use it _
Do not use Avorax Cream if you

are allergic to Acyclovir or any other
ingredients in this medicine.

are going to use it on the areas with
mucous
membranes,
eg.
inside
the
mouth, eye or vagina.
_ _
_Before you start to use it _
Tell your doctor or pharmacist before using
Avorax Cream if you:

are pregnant or plan to pregnant.

are
breast-feeding
or
plan
to
start
breast-feeding.

have any other medical problem.
_Taking other medicines _
Tell your doctor or pharmacist if you are
taking or having recently taken any other
medicines. This includes any medicines
which you have bought without a
prescription.
HOW TO USE AVORAX CREAM
_How much to use _
Apply continuously for 5-10days over the
affected skin areas:

every 3-4 hours daily, Or

5 times daily
_ _
_When to use it _
Apply as soon as infection is detected.
Follow the instruction from your doctor or
pharmacist.
_How long to use it _
Follow the duration of use that your doctor
or
pharmacist
has
suggested.
Usually
treatment is continued for another 5 days
after healing, however, please consult your
doctor or pharmacist before prolonged use
of this medicine.
_If you forget to use it _
Use it as soon as you remember. The

Ciri produk

COMPOSITION
Contains Acyclovir 5% w/w in a water miscible cream.
Chlorocresol 0.10% w/w as preservative.
PHARMACODYNAMICS
Acyclovir is an antiviral agent which is highly active in vitro
against herpes simplex virus (HSV) types I and II and varicella zoster
virus. Toxicity to mammalian host
cells is low. Acyclovir is phosphorylated after entry into herpes
infected cells to the active compound acyclovir triphosphate. The
first step in this process is dependent
on the presence of the HSV-coded thymidine kinase. Acyclovir
triphosphate acts as an inhibitor of, and substrate for, the
herpes-specified DNA polymerase, preventing
further viral DNA synthesis without affecting normal cellular
processes.
PHARMACOKINETICS
Pharmacology studies have shown only minimal systemic absorption of
acyclovir following repeated topical administration of Avorax Cream.
INDICATIONS
Avorax Cream is indicated in the treatment of herpes simplex
infections of the skin, including initial and recurrent labial and
genital herpes simplex infections.
DOSAGE AND ADMINISTRATION
For topical use only. Avorax Cream should be applied every 3 - 4 hours
or 5 times daily for 5 - 10 days. Avorax should be applied as soon as
infection is detected and
treatment must proceed for another 5 days after healing.
CONTRAINDICATIONS
It is contraindicated in patients with known hypersensitivity to
Acyclovir.
PRECAUTIONS
Acyclovir Cream is not recommended for use on mucous membranes such as
in the mouth, eye or vagina. Although no information is yet available
on the adverse
effects of use during pregnancy and nursing mothers, care should be
taken during usage in such conditions.
DRUG INTERACTIONS
No clinically significant interactions have been identified.
INCOMPATIBILITIES
None known.
USAGE DURING PREGNANCY
The use of Avorax Cream should be considered only when the potential
benefits outweigh the possibility of unknown risks however the
systemic exposure to acyclovir
from topical application of Avorax Cream is very low.
OVERDOSAGE AND TREATMENT
No untoward effects woul