Država: Malezija
Jezik: angleščina
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
TILMICOSIN PHOSPHATE
Thye Pharma Sdn. Bhd
TILMICOSIN PHOSPHATE
250ml mL
THYE PHARMA SDN. BHD.
Veterinary Package Insert TP-MECOTIL 300 SOL TILMICOSIN PHOSPHATE 300MG/ML SOLUTION PRODUCT DESCRIPTION Light brown to brown colour liquid, which contains 30% of tilmicosin phosphate in 250ml bottle. PHARMACODYNAMICS & PHARMACOKINETICS Tilmicosin is a mainly bactericidal semi-synthetic antibiotic of the macrolide group. It is believed to affect bacterial protein synthesis. Tilmicosin has a wide spectrum of activity against Gram-positive organisms and is particularly active against Pasteurella, Actinobacillus (Haemophilus) and Mycoplasma organisms of bovine, porcine and avian origin. Tilmicosin has some activity against certain Gram-negative micro-organisms. Cross resistance between tilmicosin and other macrolide antibiotics has been observed. When administered orally to chickens, turkeys and pigs with drinking water and to calves with milk replacer, tilmicosin is absorbed and moves rapidly out of the serum into areas of low pH. This results in very low serum concentrations, but detectable levels of tilmicosin are found in lung tissue as early as 6 hours after starting the treatment. In chicken or turkeys, tilmicosin is also detected in pooled air sac tissue as early as 6 hours after starting the treatment. It is also known that tilmicosin is concentrated in alveolar macrophages of swine. When administered orally to calves tilmicosin is detected in lungs after 6 hours and remains at the therapeutic level up to 60 hours from the last dose. INDICATION _Pigs: _ For the treatment and prevention of respiratory infections associated with Mycoplasma hyopneumoniae, Pasteurella multocida and Actinobacillus pleuropneumoniae when the disease has been diagnosed at the herd level. _Chickens (broilers and pullets): _ For the treatment and prevention of respiratory infections in poultry flocks associated with Mycoplasma gallisepticum and Mycoplasma synoviae when the disease has been diagnosed at the herd level. _Turkeys: _ For the treatment and prevention of respiratory infections in turkey flocks associated with Mycoplasma gall Preberite celoten dokument