AMINOPHYLLINE injection solution

Država: Združene države Amerike

Jezik: angleščina

Source: NLM (National Library of Medicine)

Aktivna sestavina:

aminophylline (UNII: 27Y3KJK423) (aminophylline - UNII:27Y3KJK423)

Dostopno od:

AMERICAN REGENT LABORATORIES, INC.

INN (mednarodno ime):

aminophylline

Sestava:

25 mg in 1 mL

Tip zastaranja:

PRESCRIPTION DRUG

Lastnosti izdelka

AMINOPHYLLINE- AMINOPHYLLINE INJECTION, SOLUTION
AMERICAN REGENT LABORATORIES, INC.
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AMINOPHYLLINE
INJECTION, USP
RX ONLY
DESCRIPTION
AMINOPHYLLINE
Aminophylline is a 2:1 complex of theophylline and ethylenediamine.
Theophylline is structurally
classified as a methylxanthine. Aminophylline occurs as a white or
slightly yellowish granule or
powder, with a slight ammoniacal odor. Aminophylline has the chemical
name 1H-Purine-2,6-dione,3,7-
dihydro-1,3-dimethyl-, compound with 1,2-ethanediamine (2:1) and is
represented by the following
structural formula:
The molecular formula of anhydrous aminophylline is C
H N O with a molecular weight of
420.43.
Each mL contains: Aminophylline (calculated as the dihydrate) 25 mg
(equivalent to 19.7 mg of
anhydrous theophylline), and is intended for intravenous
administration.
Inactive Ingredients:
Ethylenediamine ....................... 3.74 mg
Water for Injection .............................. q.s.
The pH is between 8.6 and 9.0.
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION:
Theophylline has two distinct actions in the airways of patients with
reversible obstruction; smooth
muscle relaxation (i.e., bronchodilation) and suppression of the
response of the airways to stimuli (i.e.,
non-bronchodilator prophylactic effects). While the mechanisms of
action of theophylline are not
known with certainty, studies in animals suggest that
bronchodilatation is mediated by the inhibition of
16
24
10
4
two isozymes of phosphodiesterase (PDE III and, to a lesser extent,
PDE IV) while non-bronchodilator
prophylactic actions are probably mediated through one or more
different molecular mechanisms, that
do not involve inhibition of PDE III or antagonism of adenosine
receptors. Some of the adverse effects
associated with theophylline appear to be mediated by inhibition of
PDE III (e.g., hypotension,
tachycardia, headache, and emesis) and adenosine receptor antagonism
(e.g., alterations in cerebral
blood flow).
Theophylline increases the force of contraction of diaphragmatic
muscles. This acti