Maa: Yhdysvallat
Kieli: englanti
Lähde: NLM (National Library of Medicine)
aminophylline (UNII: 27Y3KJK423) (aminophylline - UNII:27Y3KJK423)
AMERICAN REGENT LABORATORIES, INC.
aminophylline
25 mg in 1 mL
PRESCRIPTION DRUG
AMINOPHYLLINE- AMINOPHYLLINE INJECTION, SOLUTION AMERICAN REGENT LABORATORIES, INC. ---------- AMINOPHYLLINE INJECTION, USP RX ONLY DESCRIPTION AMINOPHYLLINE Aminophylline is a 2:1 complex of theophylline and ethylenediamine. Theophylline is structurally classified as a methylxanthine. Aminophylline occurs as a white or slightly yellowish granule or powder, with a slight ammoniacal odor. Aminophylline has the chemical name 1H-Purine-2,6-dione,3,7- dihydro-1,3-dimethyl-, compound with 1,2-ethanediamine (2:1) and is represented by the following structural formula: The molecular formula of anhydrous aminophylline is C H N O with a molecular weight of 420.43. Each mL contains: Aminophylline (calculated as the dihydrate) 25 mg (equivalent to 19.7 mg of anhydrous theophylline), and is intended for intravenous administration. Inactive Ingredients: Ethylenediamine ....................... 3.74 mg Water for Injection .............................. q.s. The pH is between 8.6 and 9.0. CLINICAL PHARMACOLOGY MECHANISM OF ACTION: Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects). While the mechanisms of action of theophylline are not known with certainty, studies in animals suggest that bronchodilatation is mediated by the inhibition of 16 24 10 4 two isozymes of phosphodiesterase (PDE III and, to a lesser extent, PDE IV) while non-bronchodilator prophylactic actions are probably mediated through one or more different molecular mechanisms, that do not involve inhibition of PDE III or antagonism of adenosine receptors. Some of the adverse effects associated with theophylline appear to be mediated by inhibition of PDE III (e.g., hypotension, tachycardia, headache, and emesis) and adenosine receptor antagonism (e.g., alterations in cerebral blood flow). Theophylline increases the force of contraction of diaphragmatic muscles. This acti Lue koko asiakirja