Krajina: Spojené štáty
Jazyk: angličtina
Zdroj: NLM (National Library of Medicine)
MILBEMYCIN OXIME (UNII: 0502PUN0GT) (MILBEMYCIN OXIME - UNII:0502PUN0GT)
Novartis Animal Health US, Inc.
MILBEMYCIN OXIME
MILBEMYCIN OXIME 2.3 mg
PRESCRIPTION
New Animal Drug Application
SENTINEL FLAVOR TABS- MILBEMYCIN OXIME AND LUFENURON TABLET, COATED NOVARTIS ANIMAL HEALTH US, INC. ---------- SENTINEL FLAVOR TABS SENTINEL (MILBEMYCIN OXIME•LUFENURON) FLAVOR TABS The palatable once-a-month prescription tablet that prevents heartworm disease and flea populations in dogs and puppies. SENTINEL® (milbemycin oxime/lufenuron) Flavor Tabs® also control flea populations and adult hookworms, and remove and control adult roundworm and whipworm infections in dogs and puppies. CAUTION Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. WARNINGS Not for human use. Keep this and all drugs out of the reach of children. DES CRIPTION SENTINEL Flavor Tabs are available in four tablet sizes in color-coded packages for oral administration to dogs and puppies according to their weight. (See Dosage Section). Each tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 4.55 mg/pound (10 mg/kg) body weight of lufenuron. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A (C H NO , MW 555.71) and 20% A (C H NO , MW 541.68). Milbemycin oxime is classified as a macrocyclic anthelmintic. Lufenuron is a benozylphenylurea derivative with the following chemical composition: N-[2,5- dichloro-4-(1,1,2,3,3,3, - hexafluoropropoxy)-phenylaminocarbonyl]-2,6- difluorobenzamide (C H Cl F N O , MW 511.15). Benzozylphenylurea compounds, including lufenuron, are classified as insect development inhibitors (IDIs). MODE OF ACTION Milbemycin oxime, one active ingredient in SENTINEL Flavor Tabs, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm (_Ancylostoma caninum_), roundworm (_Toxocara canis _and _Toxascaris leonina_) and whipworm (_Trichuris vulpis_) infestations when administered orally according to the recommended dosage schedule. Lufenuro Prečítajte si celý dokument