SENTINEL FLAVOR TABS milbemycin oxime and lufenuron tablet coated

Maa: Yhdysvallat

Kieli: englanti

Lähde: NLM (National Library of Medicine)

Aktiivinen ainesosa:

MILBEMYCIN OXIME (UNII: 0502PUN0GT) (MILBEMYCIN OXIME - UNII:0502PUN0GT)

Saatavilla:

Novartis Animal Health US, Inc.

INN (Kansainvälinen yleisnimi):

MILBEMYCIN OXIME

Koostumus:

MILBEMYCIN OXIME 2.3 mg

Prescription tyyppi:

PRESCRIPTION

Valtuutuksen tilan:

New Animal Drug Application

Valmisteyhteenveto

SENTINEL FLAVOR TABS- MILBEMYCIN OXIME AND LUFENURON TABLET, COATED
NOVARTIS ANIMAL HEALTH US, INC.
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SENTINEL FLAVOR TABS
SENTINEL (MILBEMYCIN OXIME•LUFENURON) FLAVOR TABS
The palatable once-a-month prescription tablet that prevents heartworm
disease and flea populations in
dogs and puppies. SENTINEL® (milbemycin oxime/lufenuron) Flavor
Tabs® also control flea
populations and adult hookworms, and remove and control adult
roundworm and whipworm infections in
dogs and puppies.
CAUTION
Federal (USA) law restricts this drug to use by or on the order of a
licensed veterinarian.
WARNINGS
Not for human use. Keep this and all drugs out of the reach of
children.
DES CRIPTION
SENTINEL Flavor Tabs are available in four tablet sizes in color-coded
packages for oral
administration to dogs and puppies according to their weight. (See
Dosage Section). Each tablet is
formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of
milbemycin oxime and 4.55 mg/pound
(10 mg/kg) body weight of lufenuron.
Milbemycin oxime consists of the oxime derivatives of
5-didehydromilbemycins in the ratio of
approximately 80% A (C
H NO , MW 555.71) and 20% A (C
H NO , MW 541.68). Milbemycin
oxime is classified as a macrocyclic anthelmintic.
Lufenuron is a benozylphenylurea derivative with the following
chemical composition: N-[2,5-
dichloro-4-(1,1,2,3,3,3, -
hexafluoropropoxy)-phenylaminocarbonyl]-2,6- difluorobenzamide
(C
H Cl
F N O , MW 511.15). Benzozylphenylurea compounds, including lufenuron,
are classified
as insect development inhibitors (IDIs).
MODE OF ACTION
Milbemycin oxime, one active ingredient in SENTINEL Flavor Tabs, is a
macrocyclic anthelmintic
which is believed to act by interfering with invertebrate
neurotransmission. Milbemycin oxime
eliminates the tissue stage of heartworm larvae and the adult stage of
hookworm (_Ancylostoma caninum_),
roundworm (_Toxocara canis _and _Toxascaris leonina_) and whipworm
(_Trichuris vulpis_) infestations when
administered orally according to the recommended dosage schedule.
Lufenuro