Krajina: Malajzia
Jazyk: angličtina
Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
PSEUDOEPHEDRINE HYDROCHLORIDE; DEXTROMETHORPHAN; DEXCHLORPHENIRAMINE MALEATE
SUNWARD PHARMACEUTICAL SDN. BHD.
PSEUDOEPHEDRINE HYDROCHLORIDE; DEXTROMETHORPHAN; DEXCHLORPHENIRAMINE MALEATE
60ml mL; 100ml mL; 120ml mL; 60 ml mL; 100 ml mL; 120 ml mL
SUNWARD PHARMACEUTICAL SDN. BHD.
PAEDICOF SYRUP Dexchlorpheniramine Maleate/Pseudoephedrine Hydrochloride/Dextromethrophan Hydrobromide (1mg/15mg/5mg per 10ml) 1 _ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What Paedicof Syrup is used for 2. How Paedicof Syrup works 3. Before you use Paedicof Syrup 4. How to use Paedicof Syrup 5. While you are using it 6. Side effects 7. Storage and disposal of Paedicof Syrup 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT PAEDICOF SYRUP IS USED FOR Paedicof Syrup is used for relief of unproductive cough and nasal congestion due to common cold or allergy. HOW PAEDICOF SYRUP WORKS The active ingredients in the medicine are dexchlorpheniramine maleate, pseudophed- rine HCl and dextromethorphan HBr. _ _ Dexchlorpheniramine is an antihistamine that helps to relieve symptoms of allergic reaction such as watery eyes, runny nose, skin rash, hives, and itching. Pseudoephedrine unblocks your nose and sinuses helping you to breathe more easily. Dextromethorphan HBr is used for temporary relief of coughs without phlegm. It is a cough suppressant that works by decreasing the feeling of needing to cough. BEFORE YOU USE PAEDICOF SYRUP _- When you must not use it _ Do not take this medicine if you: are hypersensitive to dexchlorpheniramine maleate, pseudophedrine HCl or dextromethorphan HBr, or any of the other ingredients listed at the end of the leaflet. _ _ have severe high blood pressure. _ _ have heart disorder. _ _ have astma. chronic cough or cough associated with excessive secretions. are taking medication for depression known as Monoamine Oxidase Inhibitors (MAOIs) or within 10 days of discontinuing such treatment. _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _- Before you start to use it _ Tell your doctor before taking this medicine if you: have hyperthyroidism (overactive thyroid gland). are diabetic have cardiovascular disease (disease of the heart or blood vessels). have closed-angle glaucoma (increase pre Prečítajte si celý dokument
Each 5ml contains: - Dexchlorpheniramine maleate 1mg Pseudoephedrine HCl 15 mg Dextromethorphan HBr 5 mg PAEDICOF SYRUP PRODUCT DESCRIPTION: A clear, green syrup with blackcurrant flavour. PHARMACODYNAMICS: Dextromethorphan HBr is a non-narcotic antitussive with effectiveness equal to codeine. It acts in the medulla oblongata to elevate the cough threshold. Dextromethorphan does not produce analgesia or induce tolerance and has no potential for addiction. At usual doses, it will not depress respiration or inhibit ciliary activity. Dexchlorpheniramine maleate is an anti-histamine with anti-cholinergic properties. It is capable of producing a slight to moderate sedative effect. It appears to compete with histamine for receptor sites on effector cells and are of value clinically in the prevention and relief of many allergic manifestations. It has been demonstrated that the predominant activity of the optically active isomers of chlorpheniramine is the dextro-isomer, The dextro-isomer is approximately two times more active than the racemic compound. Since dexchlorpheniramine is the dextro-isomer and active moiety of chlorpheniramine, its action and uses is similar to those of chlorpheniramine. Pseudoephedrine is a physiologically active stereoisomer of ephedrine that acts directly on alpha-adrenergic receptors and to lesser degree, beta-adrenergic receptors, The alpha-adrenergic effects are believed to result from the reduced production of cyclic adenosine 3’, 5’ monophosphate (cyclic 3’, 5’ AMP) by inhibition of the enzyme adenyl cyclase activity. Pseudoephedrine acts on alpha-adrenergic receptors in the nasal mucosa and releases norephedrine, hence producing vasoconstriction of the dilated nasal arterioles resulting in shrinkage of swollen nasal mucous membranes, reduction of tissue hyperemia, oedema and nasal decongestion and an increase in nasal airway patency. Drainage of sinus secretions is increased and obstructed Eustachian ostia may be opened. Relaxation of bronchial smooth muscle by stimulation of b Prečítajte si celý dokument