PAEDICOF SYRUP

Pays: Malaisie

Langue: anglais

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingrédients actifs:

PSEUDOEPHEDRINE HYDROCHLORIDE; DEXTROMETHORPHAN; DEXCHLORPHENIRAMINE MALEATE

Disponible depuis:

SUNWARD PHARMACEUTICAL SDN. BHD.

DCI (Dénomination commune internationale):

PSEUDOEPHEDRINE HYDROCHLORIDE; DEXTROMETHORPHAN; DEXCHLORPHENIRAMINE MALEATE

Unités en paquet:

60ml mL; 100ml mL; 120ml mL; 60 ml mL; 100 ml mL; 120 ml mL

Fabriqué par:

SUNWARD PHARMACEUTICAL SDN. BHD.

Notice patient

PAEDICOF SYRUP
Dexchlorpheniramine Maleate/Pseudoephedrine
Hydrochloride/Dextromethrophan Hydrobromide (1mg/15mg/5mg per 10ml)
1
_ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET
1. What Paedicof Syrup is used for
2. How Paedicof Syrup works
3. Before you use Paedicof Syrup
4. How to use Paedicof Syrup
5. While you are using it
6. Side effects
7. Storage and disposal of Paedicof Syrup
8. Product description
9. Manufacturer and Product Registration
Holder
10. Date of revision
WHAT PAEDICOF SYRUP IS USED FOR
Paedicof
Syrup
is
used
for
relief
of
unproductive cough and nasal congestion due
to common cold or allergy.
HOW PAEDICOF SYRUP WORKS
The active
ingredients
in the medicine are
dexchlorpheniramine maleate, pseudophed-
rine HCl and dextromethorphan HBr.
_ _
Dexchlorpheniramine is an antihistamine that
helps to relieve symptoms of allergic reaction
such as watery eyes, runny nose, skin rash,
hives, and itching.
Pseudoephedrine
unblocks
your
nose
and
sinuses helping you to breathe more easily.
Dextromethorphan HBr is used for temporary
relief of coughs without phlegm. It is a cough
suppressant
that
works
by
decreasing
the
feeling of needing to cough.
BEFORE YOU USE PAEDICOF SYRUP
_- When you must not use it _
Do not take this medicine if you:

are hypersensitive to dexchlorpheniramine
maleate,
pseudophedrine
HCl
or
dextromethorphan HBr, or any of the other
ingredients listed at the end of the leaflet.
_ _

have severe high blood pressure.
_ _

have heart disorder.
_ _

have astma.

chronic cough or cough associated with
excessive secretions.

are taking medication for depression known
as Monoamine Oxidase Inhibitors (MAOIs)
or
within 10
days of discontinuing such
treatment.
_ _
_ _
_ _
_ _
_ _
_ _
_ _
_ _
_- Before you start to use it _
Tell your doctor before taking this medicine if
you:

have hyperthyroidism (overactive thyroid
gland).

are diabetic

have cardiovascular disease (disease of the
heart or blood vessels).

have closed-angle glaucoma (increase pre

Résumé des caractéristiques du produit

Each 5ml contains: -
Dexchlorpheniramine maleate 1mg
Pseudoephedrine HCl 15 mg
Dextromethorphan HBr 5 mg
PAEDICOF SYRUP
PRODUCT DESCRIPTION:
A clear, green syrup with blackcurrant flavour.
PHARMACODYNAMICS:
Dextromethorphan HBr is a non-narcotic antitussive with effectiveness
equal to codeine. It acts in the medulla
oblongata to elevate the cough threshold. Dextromethorphan does not
produce analgesia or induce tolerance and has
no
potential
for
addiction.
At
usual
doses,
it
will
not
depress
respiration
or
inhibit
ciliary
activity.
Dexchlorpheniramine maleate is an anti-histamine with anti-cholinergic
properties. It is capable of producing a slight
to moderate sedative effect. It appears to compete with histamine for
receptor sites on effector cells and are of
value clinically in the prevention and relief of many allergic
manifestations. It has been demonstrated that the
predominant activity of the optically active isomers of
chlorpheniramine is the dextro-isomer, The dextro-isomer is
approximately two times more active than the racemic compound. Since
dexchlorpheniramine is the dextro-isomer
and active moiety of chlorpheniramine, its action and uses is similar
to those of chlorpheniramine. Pseudoephedrine
is a physiologically active stereoisomer of ephedrine that acts
directly on alpha-adrenergic receptors and to lesser
degree, beta-adrenergic receptors, The alpha-adrenergic effects are
believed to result from the reduced production
of cyclic adenosine 3’, 5’ monophosphate (cyclic 3’, 5’ AMP)
by inhibition of the enzyme adenyl cyclase activity.
Pseudoephedrine acts on alpha-adrenergic receptors in the nasal mucosa
and releases norephedrine, hence
producing vasoconstriction of the dilated nasal arterioles resulting
in shrinkage of swollen nasal mucous
membranes, reduction of tissue hyperemia, oedema and nasal
decongestion and an increase in nasal airway
patency. Drainage of sinus secretions is increased and obstructed
Eustachian ostia may be opened. Relaxation of
bronchial smooth muscle by stimulation of b