METOPROLOL TARTRATE tablet film coated

Krajina: Spojené štáty

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktívna zložka:

METOPROLOL TARTRATE (UNII: W5S57Y3A5L) (METOPROLOL - UNII:GEB06NHM23)

Dostupné z:

St Marys Medical Park Pharmacy

INN (Medzinárodný Name):

METOPROLOL TARTRATE

Zloženie:

METOPROLOL TARTRATE 25 mg

Typ predpisu:

PRESCRIPTION DRUG

Stav Autorizácia:

Abbreviated New Drug Application

Súhrn charakteristických

METOPROLOL TARTRATE - METOPROLOL TARTRATE TABLET, FILM COATED
ST MARYS MEDICAL PARK PHARMACY
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METOPROLOL TARTRATE TABLETS,USP
RX ONLY
PRESCRIBING INFORMATION
DESCRIPTION
Metoprolol Tartrate Tablets USP, metoprolol tartrate USP, is a
selective beta -adrenoreceptor
blocking agent, available as 50-and 100-mg tablets for oral
administration. Metoprolol tartrate USP is
(±)-1-(isopropylamino)-3-[_p_-(2-methoxyethyl)phenoxy]-2-propanol
(2:1) _dextro_-tartrate salt, and its
structural formula is
Metoprolol tartrate USP is a white, practically odorless, crystalline
powder with a molecular weight of
684.81. It is very soluble in water; freely soluble in methylene
chloride, in chloroform, and in alcohol;
slightly soluble in acetone; and insoluble in ether.
Each tablet for oral administration contains 25 mg, 50 mg or 100 mg of
metoprolol tartrate and the
following inactive ingredients: colloidal silicon dioxide,
croscarmellose sodium, hypromellose,
lactose anhydrous, magnesium stearate, microcrystalline cellulose,
sodium starch glycolate,
polyethylene glycol, pregelatinized starch, titanium dioxide. In
addition the 25 MG and 100 MG tablet
contain propylene glycol and sodium lauryl sulfate; the 50 MG tablet
contains D&C Red #30 and talc.
CLINICAL PHARMACOLOGY
_Mechanism of Action:_
Metoprolol tartrate is a beta -selective (cardioselective) adrenergic
receptor blocker. This preferential
effect is not absolute, however, and at higher plasma concentrations,
metoprolol tartrate also inhibits
beta -adrenoreceptors, chiefly located in the bronchial and vascular
musculature.
Clinical pharmacology studies have demonstrated the beta-blocking
activity of metoprolol, as shown by
(1) reduction in heart rate and cardiac output at rest and upon
exercise, (2) reduction of systolic blood
pressure upon exercise, (3) inhibition of isoproterenol-induced
tachycardia, and (4) reduction of reflex
orthostatic tachycardia.
_Hypertension_
The mechanism of the antihypertensive effects of beta-blocking agents
has not been fully elucidated.
H