Ország: Egyesült Államok
Nyelv: angol
Forrás: NLM (National Library of Medicine)
METOPROLOL TARTRATE (UNII: W5S57Y3A5L) (METOPROLOL - UNII:GEB06NHM23)
St Marys Medical Park Pharmacy
METOPROLOL TARTRATE
METOPROLOL TARTRATE 25 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
METOPROLOL TARTRATE - METOPROLOL TARTRATE TABLET, FILM COATED ST MARYS MEDICAL PARK PHARMACY ---------- METOPROLOL TARTRATE TABLETS,USP RX ONLY PRESCRIBING INFORMATION DESCRIPTION Metoprolol Tartrate Tablets USP, metoprolol tartrate USP, is a selective beta -adrenoreceptor blocking agent, available as 50-and 100-mg tablets for oral administration. Metoprolol tartrate USP is (±)-1-(isopropylamino)-3-[_p_-(2-methoxyethyl)phenoxy]-2-propanol (2:1) _dextro_-tartrate salt, and its structural formula is Metoprolol tartrate USP is a white, practically odorless, crystalline powder with a molecular weight of 684.81. It is very soluble in water; freely soluble in methylene chloride, in chloroform, and in alcohol; slightly soluble in acetone; and insoluble in ether. Each tablet for oral administration contains 25 mg, 50 mg or 100 mg of metoprolol tartrate and the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose anhydrous, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, polyethylene glycol, pregelatinized starch, titanium dioxide. In addition the 25 MG and 100 MG tablet contain propylene glycol and sodium lauryl sulfate; the 50 MG tablet contains D&C Red #30 and talc. CLINICAL PHARMACOLOGY _Mechanism of Action:_ Metoprolol tartrate is a beta -selective (cardioselective) adrenergic receptor blocker. This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol tartrate also inhibits beta -adrenoreceptors, chiefly located in the bronchial and vascular musculature. Clinical pharmacology studies have demonstrated the beta-blocking activity of metoprolol, as shown by (1) reduction in heart rate and cardiac output at rest and upon exercise, (2) reduction of systolic blood pressure upon exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia. _Hypertension_ The mechanism of the antihypertensive effects of beta-blocking agents has not been fully elucidated. H Olvassa el a teljes dokumentumot