ACYCLOVIR STADA CREAM

Krajina: Malajzia

Jazyk: angličtina

Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktívna zložka:

ACYCLOVIR

Dostupné z:

DKSH MALAYSIA SDN BHD

INN (Medzinárodný Name):

ACYCLOVIR

Počet v balení:

2 gm; 5 gm

Výrobca:

STADA Arzneimittel AG

Príbalový leták

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
ACYCLOVIR STADA CREAM
Acyclovir 50 mg
1
WHAT IS IN THIS LEAFLET
1.
What Acyclovir STADA Cream is
used for
2.
How
Acyclovir
STADA
Cream
works
3.
Before you use Acyclovir STADA
Cream
4.
How
to
use
Acyclovir
STADA
Cream
5.
While
you
are
using
Acyclovir
STADA Cream
6.
Side effects
7.
Storage and Disposal of Acyclovir
STADA Cream
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT
ACYCLOVIR
STADA
CREAM
IS
USED FOR
Acyclovir STADA Cream is a medicine
for
the
treatment
of
viral
infections
(antiviral
agent).
It
is
used
for
the
treatment
of
herpes
simplex
virus
infection of the skin including initial and
recurrent genital herpes labialis.
HOW ACYCLOVIR STADA CREAM WORKS
Acyclovir is an antiviral medicine, which
acts on infected cells by stopping the
virus growing.
BEFORE
YOU
USE
ACYCLOVIR
STADA
CREAM
_When you must not use it _
-
If
you
are
allergic
(hypersensitive) to acyclovir, or
any of the other ingredients of
Acyclovir STADA cream.
_Before you start to use it _
-
Please discuss with your doctor
or
pharmacist
before
using
Acyclovir STADA Cream.
-
The
situations
described
here
relate
to
certain
conditions
in
which Acyclovir STADA Cream
should
be
used
only
with
particular caution. Discuss with
your doctor, also if any of these
conditions
applied
to
you
previously.
Be
sure
to
inform
your
doctor
before
starting
therapy
if
you
are
severely
immunocompromised
(i.e.
if
your body’s immune system is
severely impaired).
_Taking other medicine _
-
No interactions with other drugs
are known to date.
HOW TO USE ACYCLOVIR STADA CREAM
_How much to use _
-
The instructions given below apply
unless your doctor has prescribed
Acyclovir STADA Cream otherwise
for you.
-
Please
comply
with
these
and/or
your
doctor’s
instructions
for
effective
and
safe
Acyclovir
STADA Cream therapy.
-
Apply
a
thin
film
of
cream
to
infected skin areas 5
times
daily
every 4 hours.
-
As you apply Acyclovir STADA
Cream, be sure to cover not only the
areas with vis

Súhrn charakteristických

Manufactured by:
STADA ARZNEIMITTEL AG, Stadastraβe 2-18, D-61118 Bad Vilbel, Germany
ACYCLOVIR STADA
®
CREAM
COMPOSITION
1 g of cream contains:
_Pharmacologically active ingredient: _Acyclovir 50mg
_Other Ingredients: _Steaoryl macrogolglycerides, Dimeticone, Cetyl
alcohol, Liquid
paraffin, White soft paraffin, Propylene glycol
PRESENTATION AND CONTENTS:
White to off-white homogenous cream
Original packages of 2g or 5g of cream
Acyclovir Stada
®
is an anti-viral drug For
external use only
INDICATIONS
Treatment of herpes simplex virus infection of the skin including
initial and
recurrent genital herpes and herpes labialis.
MODE OF ACTION
Acyclovir is a guanine derivative whose activity is essentially
confined to viral
thymidine kinase-producing human pathogenic herpes viruses,
i.e. herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and
varicella-
zoster virus (VZV). Acyclovir is not pharmacologically active until it
has
been converted by viral thymidine kinase inside virally infected cells
along
the following pathway:
Phosphorylation of acyclovir (the substrate) to acyclovir
monophosphate is
faster by viral thymidine kinase than by host cell thymidine
kinase. The relative selectivity minimizes the toxicity of acyclovir
to host cells.
Normal cellular nucleotidyl phosphotransferases then catalyse the
sequential
conversion of acyclovir monophosphate to acyclovir triphosphoate.
Acyclovir triphosphate (the active form of the drug) selectively
inhibits viral
DNA polymerase and is incorporated into viral DNA. Acyclovir
triphosphate
competitively displaces deoxyguanosine triphosphate from DNA
polymerases. Acyclovir triphosphate has higher affinity for
HSV-encoded DNA polymerase than cellular DNA polymerase (10 to 20
times
greater). It acts as a substrate for HSV-encoded DNA polymerase and,
cleaving of diphosphate is incorporated into viral DNA. However, as
acyclovir
lacks a 3-hydroxyl group, nucleotides can no longer be added by
3’,5’-
linkage, causing chain termination. Moreover, the
DNA-viral polymerase compl