País: Malásia
Língua: inglês
Origem: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ACYCLOVIR
DKSH MALAYSIA SDN BHD
ACYCLOVIR
2 gm; 5 gm
STADA Arzneimittel AG
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ ACYCLOVIR STADA CREAM Acyclovir 50 mg 1 WHAT IS IN THIS LEAFLET 1. What Acyclovir STADA Cream is used for 2. How Acyclovir STADA Cream works 3. Before you use Acyclovir STADA Cream 4. How to use Acyclovir STADA Cream 5. While you are using Acyclovir STADA Cream 6. Side effects 7. Storage and Disposal of Acyclovir STADA Cream 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT ACYCLOVIR STADA CREAM IS USED FOR Acyclovir STADA Cream is a medicine for the treatment of viral infections (antiviral agent). It is used for the treatment of herpes simplex virus infection of the skin including initial and recurrent genital herpes labialis. HOW ACYCLOVIR STADA CREAM WORKS Acyclovir is an antiviral medicine, which acts on infected cells by stopping the virus growing. BEFORE YOU USE ACYCLOVIR STADA CREAM _When you must not use it _ - If you are allergic (hypersensitive) to acyclovir, or any of the other ingredients of Acyclovir STADA cream. _Before you start to use it _ - Please discuss with your doctor or pharmacist before using Acyclovir STADA Cream. - The situations described here relate to certain conditions in which Acyclovir STADA Cream should be used only with particular caution. Discuss with your doctor, also if any of these conditions applied to you previously. Be sure to inform your doctor before starting therapy if you are severely immunocompromised (i.e. if your body’s immune system is severely impaired). _Taking other medicine _ - No interactions with other drugs are known to date. HOW TO USE ACYCLOVIR STADA CREAM _How much to use _ - The instructions given below apply unless your doctor has prescribed Acyclovir STADA Cream otherwise for you. - Please comply with these and/or your doctor’s instructions for effective and safe Acyclovir STADA Cream therapy. - Apply a thin film of cream to infected skin areas 5 times daily every 4 hours. - As you apply Acyclovir STADA Cream, be sure to cover not only the areas with vis Leia o documento completo
Manufactured by: STADA ARZNEIMITTEL AG, Stadastraβe 2-18, D-61118 Bad Vilbel, Germany ACYCLOVIR STADA ® CREAM COMPOSITION 1 g of cream contains: _Pharmacologically active ingredient: _Acyclovir 50mg _Other Ingredients: _Steaoryl macrogolglycerides, Dimeticone, Cetyl alcohol, Liquid paraffin, White soft paraffin, Propylene glycol PRESENTATION AND CONTENTS: White to off-white homogenous cream Original packages of 2g or 5g of cream Acyclovir Stada ® is an anti-viral drug For external use only INDICATIONS Treatment of herpes simplex virus infection of the skin including initial and recurrent genital herpes and herpes labialis. MODE OF ACTION Acyclovir is a guanine derivative whose activity is essentially confined to viral thymidine kinase-producing human pathogenic herpes viruses, i.e. herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella- zoster virus (VZV). Acyclovir is not pharmacologically active until it has been converted by viral thymidine kinase inside virally infected cells along the following pathway: Phosphorylation of acyclovir (the substrate) to acyclovir monophosphate is faster by viral thymidine kinase than by host cell thymidine kinase. The relative selectivity minimizes the toxicity of acyclovir to host cells. Normal cellular nucleotidyl phosphotransferases then catalyse the sequential conversion of acyclovir monophosphate to acyclovir triphosphoate. Acyclovir triphosphate (the active form of the drug) selectively inhibits viral DNA polymerase and is incorporated into viral DNA. Acyclovir triphosphate competitively displaces deoxyguanosine triphosphate from DNA polymerases. Acyclovir triphosphate has higher affinity for HSV-encoded DNA polymerase than cellular DNA polymerase (10 to 20 times greater). It acts as a substrate for HSV-encoded DNA polymerase and, cleaving of diphosphate is incorporated into viral DNA. However, as acyclovir lacks a 3-hydroxyl group, nucleotides can no longer be added by 3’,5’- linkage, causing chain termination. Moreover, the DNA-viral polymerase compl Leia o documento completo