Страна: Австралия
Язык: английский
Источник: Department of Health (Therapeutic Goods Administration)
Trimethoprim
TRIPRIM- Consumer Medicine Information Page 1 of 4 TRIPRIM TM _TRIMETHOPRIM _ CONSUMER MEDICINE INFORMATION (CMI) WHAT IS IN THIS LEAFLET This leaflet answers some common questions about TRIPRIM tablets. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking TRIPRIM against the benefits they expect it will have. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT TRIPRIM IS USED FOR The name of your medicine is TRIPRIM. The active ingredient is called _trimethoprim_. _ _ _Trimethoprim_ belongs to a group of medicines called antibiotics. TRIPRIM is used to treat urinary tract infections caused by bacteria. It works by stopping the growth of bacteria that are causing your infection. USE TRIPRIM ONLY AS DIRECTED AND CONSULT A HEALTH CARE PROFESSIONAL IF PAIN OR SYMPTOMS PERSIST. TRIPRIM is not recommended for use in children under the age of 6 years. The safety and effectiveness of TRIPRIM in children under the age of 6 years has not been established. Your doctor may have prescribed this medicine for another condition. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY TRIPRIM HAS BEEN PRESCRIBED FOR YOU. TRIPRIM tablets are only available with a doctor’s prescription. BEFORE YOU TAKE IT _WHEN YOU MUST NOT TAKE IT_ DO NOT TAKE TRIPRIM IF YOU ARE ALLERGIC TO: Trimethoprim or any other antibiotics Any of the ingredients listed at the end of this leaflet. Some of the symptoms of an allergic reaction to TRIPRIM m Прочитать полный документ
TRIPRIM- Consumer Medicine Information Page 1 of 4 PRODUCT INFORMATION TRIPRIM COMPOSITION Trimethoprim DESCRIPTION A synthetic antibacterial. Chemical name: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine. It is a white to light yellow, odourless, bitter compound. MW: 290.3: pKA 7.3. PHARMACOLOGY Trimethoprim is rapidly absorbed following oral administration. The half-life of trimethoprim ranges from 8 to 12 hours in the presence of normal renal function. Approximately 44% of the drug is protein bound in the blood. Excretion of trimethoprim is chiefly by the kidneys through glomerular filtration and tubular secretion. Urine concentrations are considerably higher than are the concentrations in the blood. After oral administration 50% to 60% of trimethoprim is excreted in the urine within 24 hours, approximately 80% of this being unmetabolised trimethoprim. Less than 4% appears in the faeces. Concentrations of trimethoprim exceed those in plasma in the case of prostatic tissue and fluid, and vaginal secretions. MICROBIOLOGY Trimethoprim blocks the formation of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. Its affinity for the bacterial dihydrofolate reductase enzyme is much stronger than for the corresponding mammalian enzyme. Thus trimethoprim selectively interferes with bacterial biosynthesis of nucleic acids and proteins. Trimethoprim is active _in vitro_ against the common urinary tract pathogens. Representative Minimum Inhibitory Concentrations for Trimethoprim Susceptible Organisms Bacteria Trimethoprim MIC mcg/mL (Range) Escherichia coli 0.05 - 1.5 Proteus mirabilis 0.5 - 1.5 Proteus (Indole positive) 0.5 - 5.0 Klebsi Прочитать полный документ