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TRIPRIM- Consumer Medicine Information
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TRIPRIM
TM
_TRIMETHOPRIM _
CONSUMER MEDICINE INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about TRIPRIM tablets.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking TRIPRIM
against the benefits they expect it
will have.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again.
WHAT TRIPRIM IS USED
FOR
The name of your medicine is
TRIPRIM. The active ingredient is
called _trimethoprim_.
_ _
_Trimethoprim_ belongs to a group
of medicines called antibiotics.
TRIPRIM is used to treat urinary
tract infections caused by bacteria.
It works by stopping the growth of
bacteria that are causing your
infection.
USE TRIPRIM ONLY AS DIRECTED
AND CONSULT A HEALTH CARE
PROFESSIONAL IF PAIN OR SYMPTOMS
PERSIST.
TRIPRIM is not recommended for
use in children under the age of 6
years.
The safety and effectiveness of
TRIPRIM in children under the
age of 6 years has not been
established.
Your doctor may have prescribed
this medicine for another
condition.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY TRIPRIM
HAS BEEN PRESCRIBED FOR YOU.
TRIPRIM tablets are only
available with a doctor’s
prescription.
BEFORE YOU TAKE IT
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE TRIPRIM IF YOU ARE
ALLERGIC TO:
Trimethoprim or any other
antibiotics
Any of the ingredients listed at
the end of this leaflet.
Some of the symptoms of an
allergic reaction to TRIPRIM m
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TRIPRIM- Consumer Medicine Information
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PRODUCT INFORMATION
TRIPRIM
COMPOSITION
Trimethoprim
DESCRIPTION
A synthetic antibacterial. Chemical name: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine.
It is a white to
light yellow, odourless, bitter compound. MW: 290.3: pKA 7.3.
PHARMACOLOGY
Trimethoprim is rapidly absorbed following oral administration. The half-life
of trimethoprim
ranges from 8 to 12 hours in the presence
of normal renal function. Approximately 44% of the
drug is protein bound in the blood.
Excretion
of trimethoprim is chiefly by the kidneys through glomerular filtration and tubular
secretion. Urine concentrations
are considerably higher than are the concentrations in the
blood. After oral administration 50% to 60% of trimethoprim is excreted in
the urine within 24
hours, approximately 80% of this being unmetabolised trimethoprim. Less than 4% appears
in the faeces. Concentrations of trimethoprim exceed those in
plasma in the case of prostatic
tissue and fluid, and vaginal secretions.
MICROBIOLOGY
Trimethoprim blocks the formation
of tetrahydrofolic acid from dihydrofolic acid by binding to
and reversibly inhibiting the enzyme
dihydrofolate reductase. Its affinity for the bacterial
dihydrofolate reductase enzyme is
much stronger than for the corresponding mammalian
enzyme. Thus trimethoprim selectively interferes with
bacterial biosynthesis of nucleic acids
and proteins.
Trimethoprim is active _in vitro_ against the common
urinary tract pathogens.
Representative
Minimum Inhibitory Concentrations for Trimethoprim Susceptible
Organisms
Bacteria
Trimethoprim MIC
mcg/mL (Range)
Escherichia coli
0.05 - 1.5
Proteus mirabilis
0.5 - 1.5
Proteus (Indole positive)
0.5 - 5.0
Klebsi
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