Pepcidine

Страна: Австралия

Язык: английский

Источник: Department of Health (Therapeutic Goods Administration)

Активный ингредиент:

Famotidine

тонкая брошюра

PEPCIDINE(R)
1
PEPCIDINE(R)
_Famotidine_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about PEPCIDINE.  It does
not contain all the available
information. 
It does not take the place of talking
to your doctor or pharmacist. 
All medicines have risks and
benefits.  Your doctor has weighed
the risks of you taking PEPCIDINE
against the benefits they expect it
will have for you. 
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST. 
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again. 
WHAT PEPCIDINE IS
USED FOR
PEPCIDINE is used to treat peptic
ulcers (gastric and duodenal ulcers),
reflux oesophagitis (reflux disease)
or a rare condition called
Zollinger-Ellison syndrome.  It is
also used to help stop duodenal
ulcers and reflux disease from
coming back. 
PEPTIC ULCERS: 
PEPCIDINE is used to heal peptic
ulcers.  Depending on the position of
the ulcer it is called a gastric or
duodenal ulcer.  A gastric ulcer
occurs in the stomach.  A duodenal
ulcer occurs in the duodenum, which
is the tube leading out of the
stomach.  These ulcers usually cause 
pain and discomfort (indigestion),
which is felt between the navel and
the breast bone.  The pain may occur
before or after meals, or in the
middle of the night. 
PEPCIDINE is also used to help stop
duodenal ulcers from coming back. 
REFLUX DISEASE: 
PEPCIDINE is used to treat reflux
oesophagitis, also called reflux
disease, and stop it from coming
back.  This condition is caused by the
washing back, or reflux, of food and
acid from the stomach into the food
pipe, also called the oesophagus.
This causes a painful burning
sensation in the chest rising up to the
throat (heartburn), and usually occurs
after eating or at night. 
ZOLLINGER-ELLISON SYNDROME: 
PEPCIDINE is used to treat a rare
condition called Zollinger-Ellison
syndrom

Характеристики продукта

 PRODUCT INFORMATION  

Tablets 

PEPCIDINE
®

(Famotidine, MSD)  

INTRODUCTION 

PEPCIDINE (famotidine, MSD) is a competitive
inhibitor of histamine H
2
-receptors. The 
primary clinically important pharmacological activity of PEPCIDINE is inhibition of gastric 
juice secretion. PEPCIDINE reduces the acid and pepsin
content, as well as the volume of 
basal, nocturnal and stimulated gastric secretion. 

DESCRIPTION 

PEPCIDINE (famotidine, MSD) is 3-[[[2-[(aminoiminomethyl) amino]-4-thiazolyl]methyl]thio]-
N-(aminosulphonyl) propanimidamide. It is a guanylthiazole
derivative with an empirical 
formula of C8 H15 N7 O2 S3 and its structural formula is: 

Famotidine is a white to pale
yellow non-hygroscopic crystalline substance with a molecular 
weight of 337.43. It is very slightly soluble in water and
practically insoluble in ethanol, 
acetone, ethylacetate, ethyl ether and
chloroform. It is freely soluble in glacial acetic acid. 

PHARMACOLOGY 

PHARMACODYNAMICS 

Gastrointestional Effects 

PEPCIDINE is a competitive inhibitor of histamine H
2
-receptors. The primary clinically 
important pharmacological activity of PEPCIDINE is inhibition of gastric secretion. Both the 
acid concentration and volume of gastric secretion are suppressed
by PEPCIDINE, while 
changes in pepsin secretion are proportional to volume output. 

In normal volunteers and
hypersecretors, PEPCIDINE inhibited basal and nocturnal gastric 
secretion, as well as secretion stimulated by food and
pentagastrin.  After oral 
administration, the onset of the antisecretory effect occurred within
one hour; the maximum 
effect was
dose-dependent, occurring within one to three hours.  Duration of inhibition of 
secretion by doses of 20 and 40mg was 10 to 12 hours. 

Single evening oral doses of 20