Valsts: Austrālija
Valoda: angļu
Klimata pārmaiņas: Department of Health (Therapeutic Goods Administration)
Famotidine
PEPCIDINE(R) 1 PEPCIDINE(R) _Famotidine_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about PEPCIDINE. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking PEPCIDINE against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT PEPCIDINE IS USED FOR PEPCIDINE is used to treat peptic ulcers (gastric and duodenal ulcers), reflux oesophagitis (reflux disease) or a rare condition called Zollinger-Ellison syndrome. It is also used to help stop duodenal ulcers and reflux disease from coming back. PEPTIC ULCERS: PEPCIDINE is used to heal peptic ulcers. Depending on the position of the ulcer it is called a gastric or duodenal ulcer. A gastric ulcer occurs in the stomach. A duodenal ulcer occurs in the duodenum, which is the tube leading out of the stomach. These ulcers usually cause pain and discomfort (indigestion), which is felt between the navel and the breast bone. The pain may occur before or after meals, or in the middle of the night. PEPCIDINE is also used to help stop duodenal ulcers from coming back. REFLUX DISEASE: PEPCIDINE is used to treat reflux oesophagitis, also called reflux disease, and stop it from coming back. This condition is caused by the washing back, or reflux, of food and acid from the stomach into the food pipe, also called the oesophagus. This causes a painful burning sensation in the chest rising up to the throat (heartburn), and usually occurs after eating or at night. ZOLLINGER-ELLISON SYNDROME: PEPCIDINE is used to treat a rare condition called Zollinger-Ellison syndrom Izlasiet visu dokumentu
PRODUCT INFORMATION Tablets PEPCIDINE ® (Famotidine, MSD) INTRODUCTION PEPCIDINE (famotidine, MSD) is a competitive inhibitor of histamine H 2 -receptors. The primary clinically important pharmacological activity of PEPCIDINE is inhibition of gastric juice secretion. PEPCIDINE reduces the acid and pepsin content, as well as the volume of basal, nocturnal and stimulated gastric secretion. DESCRIPTION PEPCIDINE (famotidine, MSD) is 3-[[[2-[(aminoiminomethyl) amino]-4-thiazolyl]methyl]thio]- N-(aminosulphonyl) propanimidamide. It is a guanylthiazole derivative with an empirical formula of C8 H15 N7 O2 S3 and its structural formula is: Famotidine is a white to pale yellow non-hygroscopic crystalline substance with a molecular weight of 337.43. It is very slightly soluble in water and practically insoluble in ethanol, acetone, ethylacetate, ethyl ether and chloroform. It is freely soluble in glacial acetic acid. PHARMACOLOGY PHARMACODYNAMICS Gastrointestional Effects PEPCIDINE is a competitive inhibitor of histamine H 2 -receptors. The primary clinically important pharmacological activity of PEPCIDINE is inhibition of gastric secretion. Both the acid concentration and volume of gastric secretion are suppressed by PEPCIDINE, while changes in pepsin secretion are proportional to volume output. In normal volunteers and hypersecretors, PEPCIDINE inhibited basal and nocturnal gastric secretion, as well as secretion stimulated by food and pentagastrin. After oral administration, the onset of the antisecretory effect occurred within one hour; the maximum effect was dose-dependent, occurring within one to three hours. Duration of inhibition of secretion by doses of 20 and 40mg was 10 to 12 hours. Single evening oral doses of 20 Izlasiet visu dokumentu