Страна: Армения
Язык: английский
Источник: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
oxytetracycline
Invesa Industrial Veterinaria
oxytetracycline
200mg/ml
solution for injection
Prescription
OXITETRACICLINA 200 L.A. PART 1 Oxytetracycline Injectable solution _ _ PART 1 SUMMARY OF PRODUCT CHARACTERISTICS, LABELLING AND LEAFLET OXITETRACICLINA 200 L.A. PART 1 Oxytetracycline Injectable solution _ _ SUMMARY OF PRODUCT CHARACTERISTICS 1.- NAME OF THE VETERINARY MEDICINAL PRODUCT OXITETRACICLINA 200 L.A. 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Oxytetracycline (dihydrate) 200 mg Magnesium chloride hexahydrate 100 mg Monoethanolamine 67.5 µ l 2-pyrrolidone 0.4 ml Sodium formaldehyde sulfoxylate 2 mg Polyvinylpyrrolidone 50 mg Water for injection q.s. 1 ml 3. PHARMACEUTICAL FORM SOLUTION FOR INJECTION 4. PHARMACOLOGYCAL PROPERTIES Pharmacotherapeutical group: Antibacterials for systemic use. ATCvet code: QJ01AA06 OXITETRACICLINA 200 L.A. PART 1 Oxytetracycline Injectable solution _ _ 4.1. PHARMACODYNAMIC PROPERTIES Oxytetracycline is a bacteriostatic antibiotic that acts on bacterial ribosomes by inhibiting the protein synthesis. It has a very broad spectrum of activity, which includes gram positive germs, gram negative germs, some big viruses, protozoa, spirochaetes, rickettsias, mycoplasmas and chlamydias. Thanks to its long-acting formula, a single injection of OXITETRACICLINA 200 L.A. can reach a complete antibiotherapy, due to the fact that efficacious blood levels are maintained for 3 days. 4.2. PHARMACOKINETIC PROPERTIES After intramuscular administration, plasmatic concentrations of oxytetracycline are detectable during the first 30 minutes, and thanks to its long-action formulation it mantains significant blood concentrations for 3 days. Once absorbed, it binds to plasmatic proteins. It is distributed in all the organism specially in lung, kidney, liver and spleen where the highest concentrations are reached as well as in active zones of ossification. It presents lower concentrations in saliva, ocular humours and milk. It also crosses placental barrier. Tetracyclines diffuse with difficulty to the cerebrospinal liquid, being in a higher degree when meninges are inflammed. It is excreted mainly Прочитать полный документ