KONAKION MM PAEDIATRIC 2 MG0.2 ML
Страна: Израиль
Язык: английский
Источник: Ministry of Health
тонкая брошюра
(PIL)
05-02-2017
Характеристики продукта
(SPC)
19-09-2022
Сообщить общественная оценка
(PAR)
19-09-2022
Активный ингредиент:
PHYTOMENADIONE
Доступна с:
TZAMAL BIO-PHARMA LTD
код АТС:
B02BA01
Фармацевтическая форма:
SOLUTION FOR INJECTION
состав:
PHYTOMENADIONE 10 MG/ML
Администрация маршрут:
I.M, I.V, PER OS
Тип рецепта:
Required
Производитель:
CHEPLAPHARM ARZNEIMITTEL GMBH, GERMANY
Терапевтическая группа:
PHYTOMENADIONE
Терапевтические области:
PHYTOMENADIONE
Терапевтические показания :
Prophylaxis and treatment of haemorrhoagic disease of the newborn.
Дата Авторизация:
2022-04-30
тонкая брошюра
ךיראת
:
2016
-
SEP
-
9
2 :םושירה רפסמו תילגנאב רישכתה םש
KONAKION MM PAEDIATRIC 2MG/0.2ML (01.5.952.7..511)
םושירה לעב םש :
ROCHE PHARMACEUTICALS (ISRAEL) LTD
! דבלב תורמחהה טורפל דעוימ הז ספוט
תושקובמה תורמחהה
ןולעב קרפ
יחכונ טסקט
שדח טסקט
PRECAUTIONS
Parenteral administration may be
associated with an increased risk of
kernicterus in premature infants
weighing less than 2.5 kg.
At the time of use, the mixed-micelle ampoule
solution must be clear in appearance. Parenteral
administration may be associated with an
increased risk of kernicterus in premature
infants weighing less than 2.5 kg.
PHARMACOKINETICS/
ELIMINATION
The half-life of vitamin K
1
in plasma
is about 1.5 to 3 hours. Vitamin K
1
is
excreted in the bile and urine as
glucuronide and sulphate conjugates.
The half-life of vitamin K
1
in plasma is about
70 hours. Vitamin K
1
is excreted in the bile
and urine as glucuronide and sulphate
conjugates.
PHARMACOKINETIC OF
ORAL VS. IV MIXED
MICELLAR VITAMIN K
PROPHYLAXIS IN
SPECIAL POPULATIONS
Infants with cholestatic liver disease
[…]
Median serum vitamin K
1
concentrations were similar in the oral
and intravenous groups at baseline
(0.92 vs. 1.15 ng/ml) rising to
approximately 10 times higher
concentrations six hours after
intravenous K
1
compared to oral
administration (139 ng/ml vs. 1.4
ng/ml).
[…]
Infants with cholestatic liver disease
[…]
Median serum vitamin K
1
concentrations were
similar in the oral and intravenous groups at
baseline (0.92 vs. 1.15 ng/ml) rising to
approximately 100 times higher concentrations
six hours after intravenous K
1
compared to
oral administration (139 ng/ml vs. 1.4 ng/ml).
[…] תושקובמה תורמחהה תונמוסמ ובש ,ןולעה
ב"צמ
בוהצ עקר לע
5
ונמוס תורמחה רדגב םניאש םייוניש
)ןולעב(
.טסקטה םוקימב םייוניש אלו יתוהמ ןכות
קר ןמסל שי .הנוש עבצב
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