Country: ইস্রায়েল
ভাষা: ইংরেজি
সূত্র: Ministry of Health
PHYTOMENADIONE
TZAMAL BIO-PHARMA LTD
B02BA01
SOLUTION FOR INJECTION
PHYTOMENADIONE 10 MG/ML
I.M, I.V, PER OS
Required
CHEPLAPHARM ARZNEIMITTEL GMBH, GERMANY
PHYTOMENADIONE
PHYTOMENADIONE
Prophylaxis and treatment of haemorrhoagic disease of the newborn.
2022-04-30
ךיראת : 2016 - SEP - 9 2 :םושירה רפסמו תילגנאב רישכתה םש KONAKION MM PAEDIATRIC 2MG/0.2ML (01.5.952.7..511) םושירה לעב םש : ROCHE PHARMACEUTICALS (ISRAEL) LTD ! דבלב תורמחהה טורפל דעוימ הז ספוט תושקובמה תורמחהה ןולעב קרפ יחכונ טסקט שדח טסקט PRECAUTIONS Parenteral administration may be associated with an increased risk of kernicterus in premature infants weighing less than 2.5 kg. At the time of use, the mixed-micelle ampoule solution must be clear in appearance. Parenteral administration may be associated with an increased risk of kernicterus in premature infants weighing less than 2.5 kg. PHARMACOKINETICS/ ELIMINATION The half-life of vitamin K 1 in plasma is about 1.5 to 3 hours. Vitamin K 1 is excreted in the bile and urine as glucuronide and sulphate conjugates. The half-life of vitamin K 1 in plasma is about 70 hours. Vitamin K 1 is excreted in the bile and urine as glucuronide and sulphate conjugates. PHARMACOKINETIC OF ORAL VS. IV MIXED MICELLAR VITAMIN K PROPHYLAXIS IN SPECIAL POPULATIONS Infants with cholestatic liver disease […] Median serum vitamin K 1 concentrations were similar in the oral and intravenous groups at baseline (0.92 vs. 1.15 ng/ml) rising to approximately 10 times higher concentrations six hours after intravenous K 1 compared to oral administration (139 ng/ml vs. 1.4 ng/ml). […] Infants with cholestatic liver disease […] Median serum vitamin K 1 concentrations were similar in the oral and intravenous groups at baseline (0.92 vs. 1.15 ng/ml) rising to approximately 100 times higher concentrations six hours after intravenous K 1 compared to oral administration (139 ng/ml vs. 1.4 ng/ml). […] תושקובמה תורמחהה תונמוסמ ובש ,ןולעה ב"צמ בוהצ עקר לע 5 ונמוס תורמחה רדגב םניאש םייוניש )ןולעב( .טסקטה םוקימב םייוניש אלו יתוהמ ןכות קר ןמסל שי .הנוש עבצב সম্পূর্ণ নথি পড়ুন