Страна: Малайзия
Язык: английский
Источник: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
BETAMETHASONE DIPROPIONATE
AVERROES PHARMACEUTICALS SDN. BHD.
BETAMETHASONE DIPROPIONATE
5gm mcg/mL
SIU GUAN CHEM. IND.CO.,LTD.
BETALIN CREAM 0.05%W/W BETAMETHASONE DIPROPIONATE PRODUCT DESCRIPTION A white cream pack in 5g tube. COMPOSITION Each gram of Betalin Cream contains 0.64mg of Betamethasone Dipropionate (0.5mg of Betamethasone). MODE OF ACTION Bethamethasone dipropionate is a corticosteroid and has anti-inflammatory, antipruritic and vasoconstrictive effects. demonstrates these activities in a sustained manner, thereby permitting twice-a-day or, in some cases, once-a-day application. PHARMACODYNAMICS AND PHARMACOKINETICS Pharmacodynamics Betalin Cream preparations contain the dipropionate ester of betamethasone which is a glucocorticoid exhibiting the general properties of corticosteroids. In pharmacological doses, corticosteroids are used primarily for their anti-inflammatory and/or immune suppressive effects. Topical corticosteroids such as betamethasone dipropionate are effective in the treatment of a range of dermatoses because of their anti-inflammatory, anti-pruritic and vasoconstrictive actions. However, while the physiologic, pharmacologic and clinical effects of the corticosteroids are well known, the exact mechanisms of their action in each disease are uncertain. PHARMACOKINETICS Betamethasone dipropionate is readily absorbed from the gastrointestinal tract and also absorbed from sites of local administration. Sufficient betamethasone dipropionate may be absorbed to give systemic effects when used topically, particularly under an occlusive dressing or when the skin is broken, or as a rectal enema. Betamethasone dipropionate are rapidly distributed to all body tissues. It crosses the placenta and may be distributed in small amounts into breast milk. Like most corticosteroids, betamethasone in the circulation are extensively bound to plasma proteins, mainly to globulin and less so to albumin. Betamethasone dipropionate is metabolized mainly in the liver but also in other tissues and excreted in urine. INDICATIONS Betalin cream is indicated for the relief of the inflammatory manifestations of corticosteroid-responsive derm Прочитать полный документ