COLESTID colestipol hydrochloride 5g granules sachets

Țară: Australia

Limbă: engleză

Sursă: Department of Health (Therapeutic Goods Administration)

Ingredient activ:

colestipol hydrochloride

Disponibil de la:

Pfizer Australia Pty Ltd

Clasă:

Medicine Registered

Statutul autorizaţiei:

Registered

Prospect

COLESTID
® GRANULES
FOR ORAL SUSPENSION
_Colestipol hydrochloride_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about COLESTID. It does
not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking COLESTID
against the benefits this medicine is
expected to have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT COLESTID IS
USED FOR
_WHAT COLESTID DOES_
COLESTID helps to lower blood
cholesterol levels. It should be used
in conjunction with a low fat diet.
Everyone has cholesterol in their
blood. It's a type of blood fat needed
by the body for many things, such as
building the lining of cells, making
bile acids (which help to digest food)
and some hormones. However, too
much cholesterol can be a problem.
COLESTID does not reduce the
amount of cholesterol that comes
from the fat in food. Therefore, you
should also follow a low fat diet and
start other measures, such as exercise
and weight control.
In most people, there are no
symptoms of high cholesterol. Your
doctor can measure your cholesterol
with a simple blood test.
_HOW COLESTID WORKS_
COLESTID contains colestipol
hydrochloride which is a kind of
resin.
COLESTID works in the intestine by
trapping bile acids and preventing
them from being reabsorbed.
COLESTID is not absorbed into the
body, but passes through the
intestine, drawing bile acids out in
the process. The decrease in the bile
acids recirculation leads to an
increase in producing new bile acids
by the liver from cholesterol, hence a
decrease in cholesterol level in the
blood.
Your doctor may have prescribed
COLESTID for another reason.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY COLESTID
HAS BEEN PRESCRIBED FOR YOU.
There is no evidence that
COLESTID is addictive.
This medicine is available only

Caracteristicilor produsului

Version: pfpcolep10913
Supersedes: pfpcolep11106
Page 1 of 9
PRODUCT INFORMATION
COLESTID
® (COLESTIPOL HYDROCHLORIDE)
NAME OF THE MEDICINE
COLESTID (colestipol hydrochloride) 5 g granules for oral suspension.
DESCRIPTION
COLESTID Granules for Oral Suspension consist of colestipol
hydrochloride which is a
hypolipidaemic agent for oral use. COLESTID is an insoluble, high
molecular weight basic
anion-exchange
copolymer
of
diethylenetriamine
and
1-chloro-2,
3-epoxypropane,
with
approximately 1 out of 5 amine nitrogens protonated (chloride form).
It is a light yellow
water-insoluble resin which is hygroscopic and swells when suspended
in water or aqueous
fluids. COLESTID is tasteless and odourless.
Inactive ingredient: Silicon dioxide.
PHARMACOLOGY
Cholesterol is the major, and probably the sole precursor of bile
acids. During normal
digestion, bile acids are secreted via the bile from the liver and
gall bladder into the intestines.
Bile acids emulsify the fat and lipid materials present in food, thus
facilitating absorption. A
major portion of the bile acids secreted is reabsorbed from the
intestines and returned via the
portal circulation to the liver, thus completing the enterohepatic
cycle. Only very small
amounts of bile acids are found in normal serum.
COLESTID binds bile acids in the intestine forming a complex that is
excreted in the faeces.
This nonsystemic action results in a partial removal of the bile acids
from the enterohepatic
circulation, preventing their reabsorption. Since COLESTID is an
anion-exchange resin, the
chloride anions of the resin can be replaced by other anions, usually
those with a greater
affinity for the resin than chloride ions.
COLESTID is hydrophilic, but it is virtually water insoluble (99.75%)
and it is not hydrolysed
by digestive enzymes. The high molecular weight polymer in COLESTID
apparently is not
absorbed. Less than 0.05% of
14
C-labelled COLESTID is excreted in the urine.
The increased faecal loss of bile acids due to COLESTID administration
leads to an increased
oxidatio