국가: 오스트레일리아
언어: 영어
출처: Department of Health (Therapeutic Goods Administration)
colestipol hydrochloride
Pfizer Australia Pty Ltd
Medicine Registered
Registered
COLESTID ® GRANULES FOR ORAL SUSPENSION _Colestipol hydrochloride_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about COLESTID. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking COLESTID against the benefits this medicine is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT COLESTID IS USED FOR _WHAT COLESTID DOES_ COLESTID helps to lower blood cholesterol levels. It should be used in conjunction with a low fat diet. Everyone has cholesterol in their blood. It's a type of blood fat needed by the body for many things, such as building the lining of cells, making bile acids (which help to digest food) and some hormones. However, too much cholesterol can be a problem. COLESTID does not reduce the amount of cholesterol that comes from the fat in food. Therefore, you should also follow a low fat diet and start other measures, such as exercise and weight control. In most people, there are no symptoms of high cholesterol. Your doctor can measure your cholesterol with a simple blood test. _HOW COLESTID WORKS_ COLESTID contains colestipol hydrochloride which is a kind of resin. COLESTID works in the intestine by trapping bile acids and preventing them from being reabsorbed. COLESTID is not absorbed into the body, but passes through the intestine, drawing bile acids out in the process. The decrease in the bile acids recirculation leads to an increase in producing new bile acids by the liver from cholesterol, hence a decrease in cholesterol level in the blood. Your doctor may have prescribed COLESTID for another reason. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY COLESTID HAS BEEN PRESCRIBED FOR YOU. There is no evidence that COLESTID is addictive. This medicine is available only 전체 문서 읽기
Version: pfpcolep10913 Supersedes: pfpcolep11106 Page 1 of 9 PRODUCT INFORMATION COLESTID ® (COLESTIPOL HYDROCHLORIDE) NAME OF THE MEDICINE COLESTID (colestipol hydrochloride) 5 g granules for oral suspension. DESCRIPTION COLESTID Granules for Oral Suspension consist of colestipol hydrochloride which is a hypolipidaemic agent for oral use. COLESTID is an insoluble, high molecular weight basic anion-exchange copolymer of diethylenetriamine and 1-chloro-2, 3-epoxypropane, with approximately 1 out of 5 amine nitrogens protonated (chloride form). It is a light yellow water-insoluble resin which is hygroscopic and swells when suspended in water or aqueous fluids. COLESTID is tasteless and odourless. Inactive ingredient: Silicon dioxide. PHARMACOLOGY Cholesterol is the major, and probably the sole precursor of bile acids. During normal digestion, bile acids are secreted via the bile from the liver and gall bladder into the intestines. Bile acids emulsify the fat and lipid materials present in food, thus facilitating absorption. A major portion of the bile acids secreted is reabsorbed from the intestines and returned via the portal circulation to the liver, thus completing the enterohepatic cycle. Only very small amounts of bile acids are found in normal serum. COLESTID binds bile acids in the intestine forming a complex that is excreted in the faeces. This nonsystemic action results in a partial removal of the bile acids from the enterohepatic circulation, preventing their reabsorption. Since COLESTID is an anion-exchange resin, the chloride anions of the resin can be replaced by other anions, usually those with a greater affinity for the resin than chloride ions. COLESTID is hydrophilic, but it is virtually water insoluble (99.75%) and it is not hydrolysed by digestive enzymes. The high molecular weight polymer in COLESTID apparently is not absorbed. Less than 0.05% of 14 C-labelled COLESTID is excreted in the urine. The increased faecal loss of bile acids due to COLESTID administration leads to an increased oxidatio 전체 문서 읽기