Țară: Australia
Limbă: engleză
Sursă: Department of Health (Therapeutic Goods Administration)
Paroxetine hydrochloride
Apotex Pty Ltd
Medicine Registered
CHEMMART PAROXETINE TABLETS _Contains the active ingredient, paroxetine hydrochloride_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about paroxetine. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on the medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is Chemmart Paroxetine. It contains the active ingredient, paroxetine (as paroxetine hydrochloride). It is used to treat: • Depression • Obsessive Compulsive Disorder (OCD) • Panic Disorder • Social Anxiety Disorder or Social Phobia • Generalised Anxiety Disorder • Post-traumatic Stress Disorder. It is also used to prevent the symptoms of Depression, Obsessive Compulsive Disorder and Panic Disorder from coming back. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. _HOW IT WORKS_ Paroxetine belongs to a group of medicines called selective serotonin reuptake inhibitors (SSRIs). They are thought to work by their action on brain chemicals called amines which are involved in controlling mood. Depression is longer lasting and/or more severe than the "low moods Citiți documentul complet
Product Information – Australia Chemmart Paroxetine Tablets Page 1 CHEMMART PAROXETINE NAME OF THE MEDICINE Paroxetine hydrochloride. Chemical Name: (-)-trans-4R-(4'-fluorophenyl)-3S-[(3',4'-methylenedioxyphenoxy) methyl]-piperidine hydrochloride. Structural Formula: Molecular Formula: C 19 H 20 FNO 3 •HCl Molecular Weight: 365.83 CAS Registry Number: 78246-49-8 DESCRIPTION Paroxetine hydrochloride is an odourless, off-white powder, with a melting point range of 120°C to 138°C and solubility of 5.4 mg/mL in water. It is the hydrochloride salt of a phenylpiperidine compound. Paroxetine is an orally administered antidepressant with a chemical structure unrelated to other selective serotonin reuptake inhibitors or to tricyclic, tetracyclic or other available antidepressant agents. PHARMACOLOGY PHARMACODYNAMICS Paroxetine is a potent and selective inhibitor of 5-hydroxytryptamine (5-HT, serotonin) uptake and its antidepressant action and efficacy in the treatment of Obsessive Compulsive Disorder, Panic Disorder, Social Anxiety Disorder/Social Phobia, Generalised Anxiety Disorder and Post-traumatic Stress Disorder is thought to be related to its specific inhibition of 5-HT uptake in brain neurones. _In vitro _studies have indicated that, in contrast to tricyclic antidepressants, paroxetine has little affinity for 1 -, 2 - and -adrenoceptors, dopamine (D 2 ), 5-HT 1 -like, 5-HT 2 and histamine (H 1 ) receptors. This lack of interaction with post-synaptic receptors _in vitro_ is substantiated by _in vivo_ studies which demonstrate lack of CNS depressant and hypotensive properties. Paroxetine has low affinity for muscarinic cholinergic receptors and anim Citiți documentul complet