PIL
CHEMMART PAROXETINE
TABLETS
_Contains the active ingredient, paroxetine hydrochloride_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about paroxetine. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
the medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is
Chemmart Paroxetine. It contains the
active ingredient, paroxetine (as
paroxetine hydrochloride).
It is used to treat:
•
Depression
•
Obsessive Compulsive Disorder
(OCD)
•
Panic Disorder
•
Social Anxiety Disorder or Social
Phobia
•
Generalised Anxiety Disorder
•
Post-traumatic Stress Disorder.
It is also used to prevent the
symptoms of Depression, Obsessive
Compulsive Disorder and Panic
Disorder from coming back.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HOW IT WORKS_
Paroxetine belongs to a group of
medicines called selective serotonin
reuptake inhibitors (SSRIs). They are
thought to work by their action on
brain chemicals called amines which
are involved in controlling mood.
Depression is longer lasting and/or
more severe than the "low moods
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Product Information
– Australia
Chemmart Paroxetine Tablets
Page 1
CHEMMART PAROXETINE
NAME OF THE MEDICINE
Paroxetine hydrochloride.
Chemical Name:
(-)-trans-4R-(4'-fluorophenyl)-3S-[(3',4'-methylenedioxyphenoxy) methyl]-piperidine
hydrochloride.
Structural Formula:
Molecular Formula:
C
19
H
20
FNO
3
•HCl
Molecular Weight:
365.83
CAS Registry Number: 78246-49-8
DESCRIPTION
Paroxetine hydrochloride is an odourless, off-white powder, with a melting point range of 120°C to 138°C
and solubility of 5.4 mg/mL in water. It is the hydrochloride salt of a phenylpiperidine compound.
Paroxetine is an orally administered antidepressant with a chemical structure unrelated to other selective
serotonin reuptake inhibitors or to tricyclic, tetracyclic or other available antidepressant agents.
PHARMACOLOGY
PHARMACODYNAMICS
Paroxetine is a potent and selective inhibitor of 5-hydroxytryptamine (5-HT, serotonin) uptake and its
antidepressant action and efficacy in the treatment of Obsessive Compulsive Disorder, Panic Disorder,
Social Anxiety Disorder/Social Phobia, Generalised Anxiety Disorder and Post-traumatic Stress Disorder
is thought to be related to its specific inhibition of 5-HT uptake in brain neurones.
_In vitro _studies have indicated that, in contrast to tricyclic antidepressants, paroxetine has little affinity for
1
-,
2
- and
-adrenoceptors, dopamine (D
2
), 5-HT
1
-like, 5-HT
2
and histamine (H
1
) receptors. This lack of
interaction with post-synaptic receptors _in vitro_ is substantiated by _in vivo_ studies which demonstrate lack
of CNS depressant and hypotensive properties. Paroxetine has low affinity for muscarinic cholinergic
receptors and anim
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