PANADOL C TABLET

País: Malásia

Língua: inglês

Origem: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredientes ativos:

PSEUDOEPHEDRINE HYDROCHLORIDE; Paracetamol

Disponível em:

GLAXOSMITHKLINE CONSUMER HEALTHCARE SDN. BHD.

DCI (Denominação Comum Internacional):

PSEUDOEPHEDRINE HYDROCHLORIDE; Paracetamol

Unidades em pacote:

10Tablet Tablets; Tablet Tablets

Fabricado por:

STERLING DRUG (MALAYA) SDN. BHD.

Folheto informativo - Bula

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
PANADOL C TABLET
Paracetamol 500mg, Pseudoephedrine hydrochloride 30mg
1
WHAT IS IN THIS LEAFLET
1.
What PANADOL C TABLET is
used for
2.
How PANADOL C TABLET works
3.
Before you use PANADOL C
TABLET
4.
How to use PANADOL C TABLET
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of PANADOL
C TABLET
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT PANADOL C TABLET
IS USED
FOR
PANADOL C TABLET is used for the
temporary relief of sinus congestion and
pain associated with rhinitis or the
common cold.
HOW PANADOL C TABLET WORKS
Each PANADOL C TABLET contains
pseudoephedrine hydrochloride and
paracetamol.
Pseudoephedrine hydrochloride is a
decongestant that temporarily relieves
nasal blockage.
Paracetamol works by relieving pain and
fever.
BEFORE YOU USE PANADOL C
TABLET
-
_When you must not use it _
Do not use if:
•
You are allergic to paracetamol,
pseudoephedrine, or any of the
other ingredients.
•
You have high blood pressure or
heart disease.
•
You are taking other medicines
for the relief of colds and flu,
congestion or blocked nose,
stimulant drugs called
amphetamines (sometimes used to
treat attention deficit disorders), or
appetite suppressants.
•
You are taking or have taken in
the past two weeks, drugs called
monoamine oxidase inhibitors
(MAOI)
•
You have kidney problems, unless
your doctor tells you to.
-
_Before you start to use it _
Check with your doctor before use if:
•
You have liver problems.
•
You have an overactive thyroid
gland, prostate gland enlargement,
irregular heartbeat, glaucoma
(excessive pressure inside your
eyes), diabetes (a condition that
causes high blood sugar) or
phaeochromocytoma (a rare
tumour of the adrenal glands
which sit above the kidneys).
•
You are pregnant or breast-
feeding.
-
_Taking other medicines _
Check with your doctor before use if:
•
You are taking medicines to
control your blood pressure,
e.g.,
medicines called alpha or beta
blockers.
�

Características técnicas

PRODUCT DESCRIPTION
A White,capsule-shaped tablet with flat edges with face marked
‘Panadol C’ consist of paracetamol
500mg and pseudoephedrine hydrochloride 30mg.
PHARMACODYNAMIC
PARACETAMOL
Paracetamol is an analgesic and antipyretic. Its mechanism of action
is believed to include
inhibition of prostaglandin synthesis, primarily within the central
nervous system
The lack of peripheral prostaglandin inhibition confers important
pharmacological properties such
as the maintenance of the protective prostaglandins within the
gastrointestinal tract. Paracetamol
is,
therefore,
particularly
suitable
for
patients
with
a
history
of
disease
or
on
concomitant
medication, where peripheral prostaglandin inhibition would be
undesirable (such as, for example,
those with a history of gastrointestinal bleeding or the elderly)
PSEUDOEPHEDRINE HYDROCHLORIDE
Pseudoephedrine is predominantly an indirect-acting sympathomimetic
amine with less direct
adrenergic effect than its epimer, ephedrine. S(+)-pseudoephedrine is
the naturally-occurring
isomer and the one used in clinical practice.
Pseudoephedrine 60 mg has been shown to be an effective nasal
decongestant, as measured by
nasal airflow, in patients with the common cold and rhinitis and
following histamine challenge in
normal subjects and in patients with allergic rhinitis.
At therapeutic doses, pseudoephedrine has no clinically significant
effect on blood pressure in
normal subjects and patients with mild to moderate hypertension.
PHARMACOKINETICS
PARACETAMOL
Paracetamol is rapidly and almost completely absorbed from the
gastrointestinal tract.
Binding to the plasma proteins is minimal at therapeutic
concentrations.
Paracetamol is metabolised in the liver and excreted in the urine
mainly as glucuronide and
sulphate conjugates.
Less than 5% is excreted as unmodified paracetamol.
PSEUDOEPHEDRINE HYDROCHLORIDE
Pseudoephedrine is rapidly and completely absorbed from the
gastrointestinal tract after oral
administration, with no presystemic metabolism.
Peak plasma levels are achiev