NOREPINEPHRINE BITARTRATE INJECTION SOLUTION

País: Canadá

Língua: inglês

Origem: Health Canada

Ingredientes ativos:

NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE MONOHYDRATE)

Disponível em:

ACALA PHARMACEUTICALS INC. (A DIVISION OF FERNBANK MANAGEMENT CORPORATION)

Código ATC:

C01CA03

DCI (Denominação Comum Internacional):

NOREPINEPHRINE

Dosagem:

1MG

Forma farmacêutica:

SOLUTION

Composição:

NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE MONOHYDRATE) 1MG

Via de administração:

INTRAVENOUS

Unidades em pacote:

100

Tipo de prescrição:

Ethical

Área terapêutica:

ALPHA-AND BETA-ADRENERGIC AGONISTS

Resumo do produto:

Active ingredient group (AIG) number: 0131301001; AHFS:

Status de autorização:

APPROVED

Data de autorização:

2021-10-14

Características técnicas

_Norepinephrine Bitartrate Injection _
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PRESCRIBING INFORMATION
NOREPINEPHRINE BITARTRATE INJECTION
1 mg / mL norepinephrine
(as norepinephrine bitartrate monohydrate)
Sterile Solution for Intravenous Infusion
Manufacturer’s Standard
Sympathomimetic Amine for Use in Hypotensive Emergencies
Preservative Free
Acala Pharmaceuticals Inc.
(a division of
Fernbank Management Corporation)
224 King Street W, Suite 1702
Toronto, ON M5H 0A6
Canada
Submission Control No: 241796
Date of Revision: October 13, 2021
_Norepinephrine Bitartrate Injection _
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DESCRIPTION
Norepinephrine (sometimes referred to as
l-arterenol/Levarterenol or l-norepinephrine)
is a
sympathomimetic amine which differs from epinephrine by the absence of
a methyl group on the
nitrogen atom.
ACTION AND CLINICAL PHARMACOLOGY
Norepinephrine functions as a powerful peripheral vasoconstrictor
(alpha-adrenergic action) and as
a potent inotropic stimulator of the heart and dilator of coronary
arteries (beta-adrenergic action).
Both of these actions result in an increase in systemic blood pressure
and coronary artery blood
flow. Cardiac output will vary reflexly in response to systemic
hypertension but is usually increased
in the hypotensive person when the blood pressure is raised to an
optimal level. In myocardial
infarction accompanied by hypotension, norepinephrine usually
increases aortic blood pressure,
coronary artery blood flow, and myocardial oxygenation, thereby
helping to limit the area of
myocardial ischemia and infarction. Venous return is increased and the
heart tends to resume a
more normal rate and rhythm than in the hypotensive state.
In hypotension that persists after correction of blood volume
deficits, norepinephrine helps raise the
blood pressure to an optimal level and establish a more adequate
circulation.
In myocardial infarction norepinephrine has been shown to increase
greatly the patient survival rate.
Norepinephrine not only corrects systemic shock (through cardiotonic
and peripheral
vasoconstrictor action), but also