Metoprolol tablets

País: Armênia

Língua: inglês

Origem: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում

Ingredientes ativos:

metoprolol (metoprolol tartrate)

Disponível em:

Arpimed LLC

Código ATC:

C07AB02

DCI (Denominação Comum Internacional):

metoprolol (metoprolol tartrate)

Dosagem:

50mg

Forma farmacêutica:

tablets

Unidades em pacote:

(30/3x10/) in blister

Tipo de prescrição:

Prescription

Status de autorização:

Registered

Data de autorização:

2015-09-24

Características técnicas

\
SUMMARY
PRODUCT
CHARACTERISTIC
(SPC)
METOPROLOL
50
MG
TABLETS
TRADE
NAME
-
MetoProlol
INTERNATIONAL
NON-PROPERTY
NAME
-
Metorpolol
tartrate
COMPOSITION
Each
tablet
contains:
active
ingredient:
metoprolol
tartrate
-
50mg
inactive
ingredients:
niicrocrystalline
cellulose
,
lactose
monohydrate
,
calcium
phosphate
dibasic
,
piridorr.,
magnesium
stearate
,
sodium
starch
glycolate
DOSAGE
FORM
Tablets
White
scored
biconvex
tablets.
PIIARMACOLOGICAL
GROUP
AND
ATC
CODE
cardiovascular,
betar-adrenoceptor
selective
antagonist;
ATC
code:
c07AB02
PHARMACOLOGICAL
ACTION
Metoprolol
is
a
betal-selective
(cardioselective)
adrenergic
blocking
agenl
Metoprolol
reduces
production
of
cAMP
from
ATP,
stimulated
by
katecholamines'
It
reduces
the
chronotrop,
dromotrop
and
batmotrop
activity
and
has
a
negative
inotrop
action
on
heart
muscles.
As
a
result
or
trrit
mechanism
the
hea*
rate
falls,
the
recovery
time
in
sinus
node
in*eases
as
well
as
the
re&actory
time
in
the
atrioventricular
node'
This
lead
to
atrial
stimuiation
and
protoogution
of
atriovenfficular
interval.
These
p(ocesses
simuitaneously
stipulate
the
less
cardiai
output
demand
of
oxygen,
and,
connected
with
these
thereafter
lessen
the
oxygen
necessity.
Al
of
th".e
mechanisms
leads
to
antianginal
effect.
Metoprolol
removes
the
activity
of
sympathetic
system,
fallen
down
the
heart
rate
in
tachycardia'
reduces
the
quantity
of
0AMP,
acting
as
a
antiarhtbmic
agent.
Metoprolol
reduces
the
renin-
angiotensin
system
activity
those
agtin
gas
thypotensive
agent'
Via
the
reciproc
mechanism
of
the
sympathetic
,yrt"*
the
periphelal
oritt*""
of
vesiels
is
increasing,
but
only
at
the
beginning
of
giving
drug
during
the
first
2-3
days'
This
preferential
jrect-is
not
absolute,
at
higher
plasma
concentrations
metoprolol
inhibits
betaz-adrenoreceptors
too,
chiefly
located
ln
the
bronchial
and
vascular
musculature'
Metoprolol
has
no
intrinsic
sympathomimetic
activity,
and
membrane-stabilizing
activity
is
detectable
only
at
;l;;
clncentfations
much
gtiuto
than
required
for
beta-blockade'
Anima