LINCO ACTINMIX POWDER

País: Malásia

Língua: inglês

Origem: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredientes ativos:

LINCOMYCIN HCL; SPECTINOMYCIN HCL

Disponível em:

RANGE PHARMA SDN. BHD.

DCI (Denominação Comum Internacional):

LINCOMYCIN HCL; SPECTINOMYCIN HCL

Unidades em pacote:

10.00 kg; 25.00 kg

Fabricado por:

RANGE PHARMA SDN. BHD.

Características técnicas

LINCO ACTINMIX POWDER
DESCRIPTION AND COMPOSITION
Linco Actinmix is a white to off white powder. Each kg contains 22g
Lincomycin and 22g Spectinomycin
PHARMACODYNAMICS
Lincomycin
It is effective primarily against gram-positive pathogens, and not
effective against gram-negative bacteria such as Neisserie gonorrhoeae
or Neisseria
meningitidis. The antibacterial activity of Lincomycin hydrochloride
is similar to the group of macrolide antibiotics to which erythromycin
belongs.
Lincomycin is one of the antibiotics of the lincosamines class. It was
first isolated beginning of the 1960s from the microorganism
Streptomyces
lincolnensis, named after the Licoln, Nebraska, where this
microorganism was first analyzed. Lincomycin hydrochloride is used
against susceptible
strains of streptococci, pneumococci, and staphylococci which usually
can also be treated with penicillin or erythromycin.
Generally, lincomycin acts by blocking protein synthesis by binding to
the 50S subunit of the ribosome and blocking peptidyltransferase
reaction,
thereby inhibiting protein synthesis of the cell. It is generally
regarded as a bacteriostatic compound.
Spectinomycin
Spectinomycin is an aminocyclitol antibiotic produced by the bacterium
Streptomyces spectabilis. It is active against a variety of aerobic
gram-
negative and gram-positive organisms, as well as Mycoplasma species.
Spectinomycin is used clinically, primarily for its activity against
gram-
negative organisms; some gram-positive organisms may also be
susceptible to this agent. It has in vitro and in vivo activity
against Mannheimia
(Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus
somnus, but anaerobic organisms are generally resistant. Spectinomycin
is usually
bacteriostatic at therapeutic doses. As an aminocyclitol antibiotic,
spectinomycin is structurally and functionally similar to the
aminoglycoside
antibiotics, which are also aminocyclitols. Spectinomycin lacks the
toxic effects of the aminoglycoside antibiotics; however, its use is
limited by the
ready devel