País: Estados Unidos
Língua: inglês
Origem: NLM (National Library of Medicine)
FERROUS FUMARATE (UNII: R5L488RY0Q) (FERROUS CATION - UNII:GW89581OWR), ASCORBIC ACID (UNII: PQ6CK8PD0R) (ASCORBIC ACID - UNII:PQ6CK8PD0R), INTRINSIC FACTOR (UNII: 70BT6OQT2Q) (INTRINSIC FACTOR - UNII:70BT6OQT2Q), CYANOCOBALAMIN (UNII: P6YC3EG204) (CYANOCOBALAMIN - UNII:P6YC3EG204)
Nnodum Pharmaceuticals
FERROUS FUMARATE
FERROUS CATION 66 mg
ORAL
PRESCRIPTION DRUG
For the treatment of all anemias responsive to oral iron therapy, such as hypochromic anemia associated with pregnancy, chronic or acute blood loss, dietary restriction, metabolic disease and post-surgical convalescence. Hemochromatosis and hemosiderosis are contraindications to iron therapy.
Each Red soft gelatin capsule is imprinted with "Ziks631" on one side. NDC 63044-0631-19 10 x 10, unit dose packs, in packs of 100's. Store at controlled between temperature 15°- 30°C (59°- 86°F). Protect from direct / excessive heat 40°C (104°F). Avoid freezing. 1 BIBLIOGRAPHY: Berk, M.S. and Novich, M.A.: 'Treatment of Iron Deficiency Anemia With Ferrous 2 Fumarate," Am. J. Obst. & Gynec., 203-206, 1962. Shapleigh, J.B., and Montgomery, A.; Am. Pract. & 3 Dig. Treat. 10-461, 1959. Brise, H. and Hallberg, L.: "Effect of Ascorbic Acid on Iron Absorption," Acta. 4 5 Med. Scand. 171 :376, 51 -58,1962. New Drugs, p. 309, AMA, Chicago, 1966. Mazur, A., Green, S. and Carleton, A.: "Mechanism of Plasma Iron Incorporation into Hepatic Ferritin," J. of Bio. Chem. 6 3:595-603, 1960. Greenberg, S.M., Tucker, A.E., Mathues, H. and J.D.: "Iron Absorption and 7 Metabolism, I. Interrelationship of Ascorbic Acid and Vitamin E," J. Nutrition 63:19-31, 1957. Moore, C. V., and Dubach, R.: "Observations on the Absorption of Iron From Foods Tagged with Radioiron, 8 "Trans. Assoc. Amer. Physic. 64:245, 1951. Steinkamp, R., Dubach, R. and Moore, C.Y. "Studies in 9 Iron Transportation and Metabolism," Arch. Int. Med. 95:181, 1955. Gorten, M.K. and Bradley, J.E.: "The Treatment of Nutritional Anemia in Infancy and Childhood with Oral Iron and Ascorbic l0 Acid,"J. Pediatrics, 45: 1, 1954. Mazur, A.: "Role of Ascorbic Acid in the Incorporation of Plasma Iron 11 into Ferritin." An. N.Y. Acad. Sci. 92:223-229, 1961. COX, E. V. et al.: "The Anemia of Scurvy," Amer. J. 12 Med. 42:220-227, 1967. Berk, L. et al.: "Observations on the Etiologic Relationship of Achylia 13 Gastrica to Pernicious Anemia, X," N. Eng. J. Med. 239:911-913, 1948. Hall, B.E.: "Studies on the 14 Nature of the Intrinsic Factor of Castle," Brit. Med. J. 2:585-589,1950. Wallerstein, R.O. et al.: "Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia, XV" J. Lab 15 & Clin. Med. 41 :363-375, 1953. Castle, W.B.: "Observations on the Etiologic Relationship of Achylia 16 Gastrica to Pernicious Anemia, 1," Am. J. Med. Sc.178:748-764, 1929.
unapproved drug other
HEMATOGEN - FERROUS FUMARATE, ASCORBIC ACID, INTRINSIC FACTOR , CYANOCOBALAMIN CAPSULE NNODUM PHARMACEUTICALS _Disclaimer: This drug has not been found by FDA to be safe and effective, and this_ _labeling has not been approved by FDA. For further information about unapproved_ _drugs, click here._ ---------- HEMATOGEN SOFTGEL CAPSULE Ferrous fumarate (66 mg elemental iron) USP................... 200 mg Ascorbic acid USP.................................................................. 250 mg Desiccated stomach powder................................................... 100 mg (Contains: Intrinsic factor), Cyanocobalamin USP...............................................................10 mcg DISCUSSION: The amount of elemental iron and the absorption of the iron components of commercial iron preparations vary widely. It is further established that certain "accessory components" may be included to enhance absorption and utilization of iron. Hematogen™ Capsules are formulated to provide the essential factors for a complete, versatile hematinic. ACTIONS/CLINICAL PHARMACOLOGY HIGH ELEMENTAL IRON CONTENT: Ferrous fumarate, used in Hematogen™ Capsules, is an organic iron complex which has the highest elemental iron content of any hematinic salt-33%. This compares with 20% for ferrous sulfate (heptahydrate) and 13% for ferrous gluconate. Hematogen™ contains 66 mg of elemental iron. MORE COMPLETE ABSORPTION: It has been repeatedly shown that ascorbic acid, when given in sufficient amounts, can increase the absorption of ferrous iron from the gastrointestinal tract. The absorption promoting effect is mainly due to the reducing action of ascorbic acid within the gastro intestinal lumen, which helps to prevent or delay the formation of insoluble or less dissociated ferric compounds. Iron absorption has been shown to increase sharply with increasing amounts of ascorbic acid, showing a gain in absorption of approximately 40% at 250 mg. Above 250 mg, the gain becomes insignificant, with an additional gain of only approximat Leia o documento completo