HEMATOGEN- ferrous fumarate, ascorbic acid, intrinsic factor , cyanocobalamin capsule

Country: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

FERROUS FUMARATE (UNII: R5L488RY0Q) (FERROUS CATION - UNII:GW89581OWR), ASCORBIC ACID (UNII: PQ6CK8PD0R) (ASCORBIC ACID - UNII:PQ6CK8PD0R), INTRINSIC FACTOR (UNII: 70BT6OQT2Q) (INTRINSIC FACTOR - UNII:70BT6OQT2Q), CYANOCOBALAMIN (UNII: P6YC3EG204) (CYANOCOBALAMIN - UNII:P6YC3EG204)

থেকে পাওয়া:

Nnodum Pharmaceuticals

INN (International Name):

FERROUS FUMARATE

রচনা:

FERROUS CATION 66 mg

প্রশাসন রুট:

ORAL

প্রেসক্রিপশন টাইপ:

PRESCRIPTION DRUG

থেরাপিউটিক ইঙ্গিত:

For the treatment of all anemias responsive to oral iron therapy, such as hypochromic anemia associated with pregnancy, chronic or acute blood loss, dietary restriction, metabolic disease and post-surgical convalescence. Hemochromatosis and hemosiderosis are contraindications to iron therapy.

পণ্য সারাংশ:

Each Red soft gelatin capsule is imprinted with "Ziks631" on one side. NDC 63044-0631-19 10 x 10, unit dose packs, in packs of 100's. Store at controlled between temperature 15°- 30°C (59°- 86°F). Protect from direct / excessive heat 40°C (104°F). Avoid freezing. 1 BIBLIOGRAPHY: Berk, M.S. and Novich, M.A.: 'Treatment of Iron Deficiency Anemia With Ferrous 2 Fumarate," Am. J. Obst. & Gynec., 203-206, 1962. Shapleigh, J.B., and Montgomery, A.; Am. Pract. & 3 Dig. Treat. 10-461, 1959. Brise, H. and Hallberg, L.: "Effect of Ascorbic Acid on Iron Absorption," Acta. 4 5 Med. Scand. 171 :376, 51 -58,1962. New Drugs, p. 309, AMA, Chicago, 1966. Mazur, A., Green, S. and Carleton, A.: "Mechanism of Plasma Iron Incorporation into Hepatic Ferritin," J. of Bio. Chem. 6 3:595-603, 1960. Greenberg, S.M., Tucker, A.E., Mathues, H. and J.D.: "Iron Absorption and 7 Metabolism, I. Interrelationship of Ascorbic Acid and Vitamin E," J. Nutrition 63:19-31, 1957. Moore, C. V., and Dubach, R.: "Observations on the Absorption of Iron From Foods Tagged with Radioiron, 8 "Trans. Assoc. Amer. Physic. 64:245, 1951. Steinkamp, R., Dubach, R. and Moore, C.Y. "Studies in 9 Iron Transportation and Metabolism," Arch. Int. Med. 95:181, 1955. Gorten, M.K. and Bradley, J.E.: "The Treatment of Nutritional Anemia in Infancy and Childhood with Oral Iron and Ascorbic l0 Acid,"J. Pediatrics, 45: 1, 1954. Mazur, A.: "Role of Ascorbic Acid in the Incorporation of Plasma Iron 11 into Ferritin." An. N.Y. Acad. Sci. 92:223-229, 1961. COX, E. V. et al.: "The Anemia of Scurvy," Amer. J. 12 Med. 42:220-227, 1967. Berk, L. et al.: "Observations on the Etiologic Relationship of Achylia 13 Gastrica to Pernicious Anemia, X," N. Eng. J. Med. 239:911-913, 1948. Hall, B.E.: "Studies on the 14 Nature of the Intrinsic Factor of Castle," Brit. Med. J. 2:585-589,1950. Wallerstein, R.O. et al.: "Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia, XV" J. Lab 15 & Clin. Med. 41 :363-375, 1953. Castle, W.B.: "Observations on the Etiologic Relationship of Achylia 16 Gastrica to Pernicious Anemia, 1," Am. J. Med. Sc.178:748-764, 1929.

অনুমোদন অবস্থা:

unapproved drug other

পণ্য বৈশিষ্ট্য

HEMATOGEN - FERROUS FUMARATE, ASCORBIC ACID, INTRINSIC FACTOR ,
CYANOCOBALAMIN CAPSULE
NNODUM PHARMACEUTICALS
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
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HEMATOGEN SOFTGEL CAPSULE
Ferrous fumarate (66 mg elemental iron) USP................... 200 mg
Ascorbic acid
USP..................................................................
250 mg
Desiccated stomach
powder................................................... 100 mg
(Contains: Intrinsic factor),
Cyanocobalamin
USP...............................................................10
mcg
DISCUSSION: The amount of elemental iron and the absorption of the
iron components
of commercial iron preparations vary widely. It is further established
that certain
"accessory components" may be included to enhance absorption and
utilization of iron.
Hematogen™ Capsules are formulated to provide the essential factors
for a complete,
versatile hematinic.
ACTIONS/CLINICAL PHARMACOLOGY
HIGH ELEMENTAL IRON CONTENT: Ferrous fumarate, used in Hematogen™
Capsules, is an organic iron complex which has the highest elemental
iron content of
any hematinic salt-33%. This compares with 20% for ferrous sulfate
(heptahydrate) and
13% for ferrous gluconate. Hematogen™ contains 66 mg of elemental
iron.
MORE COMPLETE ABSORPTION: It has been repeatedly shown that ascorbic
acid,
when given in sufficient amounts, can increase the absorption of
ferrous iron from the
gastrointestinal tract. The absorption promoting effect is mainly due
to the reducing
action of ascorbic acid within the gastro intestinal lumen, which
helps to prevent or delay
the formation of insoluble or less dissociated ferric compounds.
Iron absorption has been shown to increase sharply with increasing
amounts of
ascorbic acid, showing a gain in absorption of approximately 40% at
250 mg. Above 250
mg, the gain becomes insignificant, with an additional gain of only
approximat