Kraj: Australia
Język: angielski
Źródło: Department of Health (Therapeutic Goods Administration)
atropine sulfate monohydrate
BPPR Consulting
atropine sulfate monohydrate
Medicine Registered
Registered
ATROPINE SULFATE INJECTION MINIJET® 1 ATROPINE SULFATE INJECTION MINIJET® CONSUMER MEDICINE INFORMATION You may have been given this product in an emergency situation by a non-medical health professional. WHAT IS IN THIS LEAFLET? This leaflet contains information about Atropine Sulfate Injection MINIJET. Please read it carefully and keep it for future reference. The information in this leaflet is only a summary and is not intended to replace advice from your doctor. Please consult your doctor or pharmacist if you have any comments or questions. WHAT IS ATROPINE? Atropine stops the effect of a chemical which we have in our bodies which slows the heartbeat, makes us produce saliva in our mouths and helps us to digest our food. The poison in mushrooms contains a similar chemical. Atropine therefore can increase the heartbeat, slow the digestive processes and act as an antidote to mushroom poisoning. WHEN IS ATROPINE USED? Atropine is used in emergency situations where the heart is beating too slowly. It can also be used to prevent such emergencies. Atropine is also very effective for treating people who become ill as a result of eating poisonous mushrooms. Atropine is occasionally used before a general anaesthetic to dry up saliva and fluid in the lungs. As atropine is only used in medical emergencies, the injection may be given by paramedical personnel such as ambulance or nursing staff. WHO SHOULD _NOT _HAVE ATROPINE INJECTIONS? As atropine is often used in medical emergencies it should rarely be withheld from anyone who needs it. Apart from this situation, atropine should NOT be used if you: • are allergic to it • have had a previous severe reaction to it • have trouble passing urine • have certain heart conditions • have high pressure in the eye (glaucoma) • have heartburn • have certain stomach problems such as pyloric stenosis • have certain bowel problems such as severe ulcerative colitis or bowel obstruction • have myasthenia gravis. BEFORE YOU HAVE AN ATROPINE INJECTION If you are consci Przeczytaj cały dokument
1 ATROPINE SULFATE INJECTION PRODUCT INFORMATION DESCRIPTION Atropine is (1_R_,3_r_,5_S_,8_r_)-tropan-3-yl-(±)-tropate sulfate monohydrate; (C 17 H 23 NO 3 ) 2 H 2 SO 4 .H 2 O. It is an odourless, bitter tasting, crystalline powder and is an alkaloid which is widely distributed in nature, especially in the deadly nightshade plant, Atropa belladonna. _CAS_ 5908-99-6. Its chemical structure is: Atropine Sulfate Injection, B.P., is a sterile solution of atropine sulfate in water. Each mL of injection contains 0.1 mg of atropine sulfate. The injection also contains sodium chloride, sodium citrate and citric acid monohydrate. PHARMACOLOGY Atropine is an antimuscarinic agent which competitively antagonizes acetylcholine at postganglionic nerve endings, thus affecting receptors of the exocrine glands, smooth muscle, cardiac muscle and the central nervous system. Peripheral effects include tachycardia, decreased production of saliva, sweat, bronchial, nasal, lachrymal and gastric secretions, decreased intestinal motility and inhibition of micturition. Atropine increases sinus rate and sinoatrial and AV conduction by blocking vagal tone. The heart rate is usually increased but is sometimes preceded by an initial bradycardia. Atropine inhibits secretions throughout the respiratory tract and relaxes bronchial smooth muscle, producing bronchodilatation. Peak plasma concentrations of atropine after intramuscular administration are reached within 30 minutes. The elimination half life varies between 2 and 5 hours. Plasma levels after intramuscular and intravenous injection are comparable after one hour. Atropine is distributed widely throughout the body and crosses the blood brain barrier and placenta. Up to 50% of the dose is protein bound. 2 Peak effects on the heart occur within 4 minutes of intravenous and about 1 hour after intramuscular administration. Atropine is metabolised in the liver by oxidation and conjugation to give inactive metabolites. About 50% of the dose is excreted within 4 hours and 90% in 24 hours in the Przeczytaj cały dokument