Min-I-Jet Atropine Sulphate 1mg/10mL injection syringe vial

Država: Australija

Jezik: engleski

Izvor: Department of Health (Therapeutic Goods Administration)

Aktivni sastojci:

atropine sulfate monohydrate

Dostupno od:

BPPR Consulting

INN (International ime):

atropine sulfate monohydrate

Razred:

Medicine Registered

Status autorizacije:

Registered

Uputa o lijeku

ATROPINE SULFATE INJECTION MINIJET®
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ATROPINE SULFATE
INJECTION MINIJET®
CONSUMER MEDICINE INFORMATION
You may have been given this product in an emergency situation by a
non-medical health professional.
WHAT IS IN THIS
LEAFLET?
This leaflet contains information
about Atropine Sulfate Injection
MINIJET. Please read it
carefully and keep it for future
reference. The information in
this leaflet is only a summary
and is not intended to replace
advice from your doctor.
Please consult your doctor or
pharmacist if you have any
comments or questions.
WHAT IS ATROPINE?
Atropine stops the effect of a
chemical which we have in our
bodies which slows the
heartbeat, makes us produce
saliva in our mouths and helps
us to digest our food. The
poison in mushrooms contains a
similar chemical. Atropine
therefore can increase the
heartbeat, slow the digestive
processes and act as an
antidote to mushroom
poisoning.
WHEN IS ATROPINE
USED?
Atropine is used in emergency
situations where the heart is
beating too slowly. It can also
be used to prevent such
emergencies. Atropine is also
very effective for treating people
who become ill as a result of
eating poisonous mushrooms.
Atropine is occasionally used
before a general anaesthetic to
dry up saliva and fluid in the
lungs.
As atropine is only used in
medical emergencies, the
injection may be given by
paramedical personnel such as
ambulance or nursing staff.
WHO SHOULD _NOT _HAVE
ATROPINE INJECTIONS?
As atropine is often used in
medical emergencies it should
rarely be withheld from anyone
who needs it.
Apart from this situation,
atropine should NOT be used if
you:
•
are allergic to it
•
have had a previous severe
reaction to it
•
have trouble passing urine
•
have certain heart conditions
•
have high pressure in the eye
(glaucoma)
•
have heartburn
•
have certain stomach
problems such as pyloric
stenosis
•
have certain bowel problems
such as severe ulcerative
colitis or bowel obstruction
•
have myasthenia gravis.
BEFORE YOU HAVE AN
ATROPINE INJECTION
If you are consci

Svojstava lijeka

1
ATROPINE SULFATE INJECTION
PRODUCT INFORMATION
DESCRIPTION
Atropine is (1_R_,3_r_,5_S_,8_r_)-tropan-3-yl-(±)-tropate sulfate
monohydrate; (C
17
H
23
NO
3
)
2
H
2
SO
4
.H
2
O. It is an
odourless, bitter tasting, crystalline powder and is an alkaloid which
is widely distributed in nature, especially
in the deadly nightshade plant, Atropa belladonna. _CAS_ 5908-99-6.
Its chemical structure is:
Atropine Sulfate Injection, B.P., is a sterile solution of atropine
sulfate in water. Each mL of injection
contains 0.1 mg of atropine sulfate. The injection also contains
sodium chloride, sodium citrate and citric
acid monohydrate.
PHARMACOLOGY
Atropine is an antimuscarinic agent which competitively antagonizes
acetylcholine at postganglionic nerve
endings, thus affecting receptors of the exocrine glands, smooth
muscle, cardiac muscle and the central
nervous system.
Peripheral effects include tachycardia, decreased production of
saliva, sweat, bronchial, nasal, lachrymal
and gastric secretions, decreased intestinal motility and inhibition
of micturition.
Atropine increases sinus rate and sinoatrial and AV conduction by
blocking vagal tone. The heart rate is
usually increased but is sometimes preceded by an initial bradycardia.
Atropine inhibits secretions throughout the respiratory tract and
relaxes bronchial smooth muscle, producing
bronchodilatation.
Peak plasma concentrations of atropine after intramuscular
administration are reached within 30 minutes.
The elimination half life varies between 2 and 5 hours. Plasma levels
after intramuscular and intravenous
injection are comparable after one hour. Atropine is distributed
widely throughout the body and crosses the
blood brain barrier and placenta. Up to 50% of the dose is protein
bound.
2
Peak effects on the heart occur within 4 minutes of intravenous and
about 1 hour after intramuscular
administration. Atropine is metabolised in the liver by oxidation and
conjugation to give inactive metabolites.
About 50% of the dose is excreted within 4 hours and 90% in 24 hours
in the