Land: Australia
Språk: engelsk
Kilde: Department of Health (Therapeutic Goods Administration)
Nitrofurantoin
Pfizer Australia Pty Ltd
Medicine Registered
MACRODANTIN ® _Nitrofurantoin_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET Please read this leaflet carefully before you start taking MACRODANTIN. This leaflet answers some common questions about MACRODANTIN. It does not contain all the available information and it does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking this medicine against the expected benefits it will have for you. Take MACRODANTIN as instructed and follow the advice given in this leaflet. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. Keep this leaflet with the medicine. You may need to read it again. WHAT MACRODANTIN IS USED FOR MACRODANTIN is used to treat infections of the urinary system caused by bacteria, for example, bladder infections. MACRODANTIN is an antibiotic which belongs to a group of medicines called nitrofurans. It works by killing or stopping the growth of the bacteria and other organisms causing these infections. Your doctor may have prescribed MACRODANTIN for another reason. Ask your doctor if you have any questions about why MACRODANTIN has been prescribed for you. These medicines are only available with a doctor's prescription. BEFORE YOU TAKE MACRODANTIN _WHEN YOU MUST NOT TAKE IT_ DO NOT TAKE MACRODANTIN IF: 1. you have an allergy to MACRODANTIN or any other nitrofuran, or to any of the ingredients listed at the end of this leaflet. Symptoms of an allergic reaction include skin rash, itching, difficulty with breathing, fever and chills. 2. you have severe kidney problems. 3. you are pregnant and close to giving birth. INFANTS UNDER ONE MONTH OF AGE SHOULD NOT BE GIVEN MACRODANTIN. Do not use MACRODANTIN if the packaging is torn or shows signs of tampering. Do not use it after the expiry date (EXP) printed on the pack. _BEFORE YOU START TAKING IT_ YOU MUST TELL YOUR DOCTOR IF: 1. you are pregnant or intend to become pregnant. Your doctor will d Les hele dokumentet
Version: pfpmacrc10513 Page 1 of 9 Supersedes: pfpmacrc10413 PRODUCT INFORMATION MACRODANTIN CAPSULES 50 MG AND 100 MG (NITROFURANTOIN MACROCRYSTALS) NAME OF THE MEDICINE Nitrofurantoin has the following chemical structure: Nitrofurantoin has the following molecular formula, molecular weight and Chemical Abstracts Service (CAS) Registry number: C 8 H 6 N 4 O 5 , 238.2, CAS-67-20-9. DESCRIPTION Nitrofurantoin, 1-(5-nitrofurfurylideneamino) hydantoin, is a synthetic antibacterial nitrofuran derivative. It occurs as lemon yellow crystals, or fine powder, and is very slightly soluble in water or alcohol. However, solubility of the drug in water and urine increases with rises in pH. The sodium salt occurs as an orange coloured powder and is soluble in water. Nitrofurantoin darkens on exposure to light or to alkali and is decomposed upon contact with metals other than stainless steel or aluminium. In view of this, the drug should be dispensed in amber coloured bottles. NOTE: MACRODANTIN (nitrofurantoin macrocrystals) is a larger crystal form of nitrofurantoin. The absorption of MACRODANTIN is slower and the excretion of MACRODANTIN is somewhat less, when the two are compared. The reduced incidence of gastrointestinal intolerance with MACRODANTIN is probably due to delayed and decreased absorption; this however does not significantly reduce clinical effectiveness. A number of patients who cannot tolerate nitrofurantoin tablets can take MACRODANTIN capsules without nausea. PHARMACOLOGY MICROBIOLOGY MACRODANTIN is bacteriostatic at low concentrations (1:100,000 to 1:200,000) an Les hele dokumentet