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MACRODANTIN
®
_Nitrofurantoin_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
Please read this leaflet carefully
before you start taking
MACRODANTIN. This leaflet
answers some common questions
about MACRODANTIN. It does not
contain all the available information
and it does not take the place of
talking to your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking this medicine
against the expected benefits it will
have for you.
Take MACRODANTIN as instructed
and follow the advice given in this
leaflet.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
Keep this leaflet with the medicine.
You may need to read it again.
WHAT MACRODANTIN
IS USED FOR
MACRODANTIN is used to treat
infections of the urinary system
caused by bacteria, for example,
bladder infections.
MACRODANTIN is an antibiotic
which belongs to a group of
medicines called nitrofurans. It
works by killing or stopping the
growth of the bacteria and other
organisms causing these infections.
Your doctor may have prescribed
MACRODANTIN for another
reason. Ask your doctor if you have
any questions about why
MACRODANTIN has been
prescribed for you.
These medicines are only available
with a doctor's prescription.
BEFORE YOU TAKE
MACRODANTIN
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE MACRODANTIN IF:
1. you have an allergy to
MACRODANTIN or any other
nitrofuran, or to any of the
ingredients listed at the end of
this leaflet. Symptoms of an
allergic reaction include skin
rash, itching, difficulty with
breathing, fever and chills.
2. you have severe kidney problems.
3. you are pregnant and close to
giving birth.
INFANTS UNDER ONE MONTH OF AGE
SHOULD NOT BE GIVEN
MACRODANTIN.
Do not use MACRODANTIN if the
packaging is torn or shows signs of
tampering.
Do not use it after the expiry date
(EXP) printed on the pack.
_BEFORE YOU START TAKING IT_
YOU MUST TELL YOUR DOCTOR IF:
1. you are pregnant or intend to
become pregnant. Your doctor
will d
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Version: pfpmacrc10513
Page 1 of 9
Supersedes: pfpmacrc10413
PRODUCT INFORMATION
MACRODANTIN
CAPSULES 50 MG AND 100 MG
(NITROFURANTOIN MACROCRYSTALS)
NAME OF THE MEDICINE
Nitrofurantoin has the following chemical structure:
Nitrofurantoin has the following molecular formula, molecular weight and Chemical Abstracts
Service (CAS) Registry number: C
8
H
6
N
4
O
5
, 238.2, CAS-67-20-9.
DESCRIPTION
Nitrofurantoin, 1-(5-nitrofurfurylideneamino) hydantoin, is a synthetic antibacterial nitrofuran
derivative. It occurs as lemon yellow crystals, or fine powder, and is very slightly soluble in
water or alcohol. However, solubility of the drug in water and urine increases with rises in pH.
The sodium salt occurs as an orange coloured powder and is soluble in water. Nitrofurantoin
darkens on exposure to light or to alkali and is decomposed upon contact with metals other than
stainless steel or aluminium. In view of this, the drug should be dispensed in amber coloured
bottles.
NOTE: MACRODANTIN (nitrofurantoin macrocrystals) is a larger crystal form of
nitrofurantoin. The absorption of MACRODANTIN is slower and the excretion of
MACRODANTIN is somewhat less, when the two are compared. The reduced incidence of
gastrointestinal intolerance with MACRODANTIN is probably due to delayed and decreased
absorption; this however does not significantly reduce clinical effectiveness. A number of
patients who cannot tolerate nitrofurantoin tablets can take MACRODANTIN capsules without
nausea.
PHARMACOLOGY
MICROBIOLOGY
MACRODANTIN is bacteriostatic at low concentrations (1:100,000 to 1:200,000) an
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