Land: Armenia
Språk: engelsk
Kilde: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
atenolol
Apotex Inc.
C07AB03
atenolol
50mg
tablets
(30/3x10/) in blister, (100) in plastic container
Prescription
Registered
2017-06-05
READ THIS FOR SAFE AND EFFECTIVE USE OF YOUR MEDICINE PATIENT MEDICATION INFORMATION B npo-nrE¡lot atenolol tablets Read this carefully before you start taking APO-ATENOL and each time you get a refill. This leaflet is a summãry and will not tell you everything about this drug. Talk to your healthcare professional about your medical condition and treatment and ask if there is any new information about APO-ATENOL. What is APO-ATENOL used for? APO-ATENOL is used to treat high blood pressure (also known as hypertension) in adults. lt can be used alone or with other medicines. APCI-ATENOL is also used to prevent chest pain (also known as angina) in adults. How does APO-ATENOL work? APO-ATENOL belongs to a group of drugs called "beta blockers". lt makes your heart beat more slowly and less forcefully. This medicine does not cure your disease but helps to control it What are the ingredients in APO-ATENOL? Medicinal ingredients: atenolol Non-medicinal ingredients: colloidal silicon dioxide, crospovidone, magnesium stearate and microcrystalline cellulose, APO-ATENOL comes in the following dosage forms: Tablets: 50 mg and 100 mg Do not :-i use APO-ATENOL if you: are allergic to atenolol or any of the ingredients in APO-ATENOL. have slow or irregular heartbeats or if you have been told that you have heart block. have severe heart damage and your heart is not able to pump enough blood to meet your body's needs. have heart failure and you notice that your symptoms are getting worse. For example you feel more tired, are out of breath more often, or have swelling of the ankles. have a problem with your heart's electrical conduction (that causes you to have chest pain, difficulty breathing, nausea, fatigue and fainting). have low blood pressure. have serious problems with blood flow in your feet and legs (peripheral artery disease). have loss of sensation with agents that cause heart failure. have a condition called pheochromocytoma (a tumour of the adrenal gland). have a condition called metabolic acidosis (abnormal levels o Les hele dokumentet
PRODUCT MpNOGRAPH Glnpo-erENoL Atenolol Tablets Apotex Standard 50 and 100 mg Beta-adrenergic receptor blocking agent APOTEX INC. 150 Signet Drive Weston, Ontario MgL IT9 DATE OF PREPARATION: June 29, 1988 DATE OF REVISION: November t4,2016 0 EF rru ÅPPR0\Itn IXPERT/O ÀP P t I I A tl û U TIIIT A Control Number:TBD 1Q o$t* PRODUCT MONOGRAPH f,lnpo-nrENol Atenolol Tablets APotex Standard 50 and 100 mg THERAPEUTIC CLASSIFICATION Beta-adrenergic receptor blocking agent ACTIONS AND CLINICAL PHARMACOLOGY Atenolol is a betar-selectlve, beta adrenergic blocking agent, devoid of membrane stabilizing or intrinsic sympathomimetic (partial agonist) activities. lt is a racemic mixture and the betar- óràpert¡eé r"siOe in the Sþj enantiomer. Betar-selectivity decreases with increasing dose. The mechanism of the antihypertensive effect has not been established. Among the factors that may be involved are: ã¡ competitive ability to antagonize catecholamine-induced tachycardia at the beta-receptor sites in the heart, thus decreasing cardiac ouiput b) inhibition of renin release by the kidneys c) inhibition of the vasomotor centres The mechanism of the anti-anginal effect is also uncertain. An important factor may be the reduction of myocardial oxygeñ requirements by blocking catecholamine-induced increases in heart rate, sysiolic blood prãssure, and the velocity and extent of myocardial contraction. ln man atenolol reduces both isoproterenol- and exercise-induced increases in heart rate over the Uor" r.ng" of 50 to 200 mg. At an oraldose of 100 mg the betar blocking effects persist for at least 24 ñorrs; the reductiõn in exercise-induced heart rate increase being about 37o/o ând 13o/o, Z and 24 hours after dosing, respectively. The logarithm of the plasma atenolol level correlates with the degree of betar blõckade but not with the antihypertensive effect. Pharmacokinetics Approximately 40 to 50o/o of an oral dose of atenolol is absorbed from the gastroíntestinaltract, tire remainder o"ing excreted unchanged in the Les hele dokumentet