Land: Maleisië
Taal: Engels
Bron: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CARPROFEN
Zoetis Malaysia Sdn. Bhd.
CARPROFEN
60 tablet Tablets
Zoetis Inc.
RIMADYL CHEWABLE TABLETS 25 MG: Each tablet contains 25 mg of Carprofen. RIMADYL CHEWABLE TABLETS 75 MG: Each tablet contains 75 mg of Carprofen. RIMADYL CHEWABLE TABLETS 100 MG: Each tablet contains 100 mg of Carprofen. PRODUCT DESCRIPTION: _Rimadyl Chewable Tablets 25 mg: _ A light brown rounded square tablet. Tablet is debossed “R” on one side, and bisected with “25 mg” on the opposite side. _Rimadyl Chewable Tablets 75 mg: _ A light brown rounded square tablet. Tablet is debossed “R” on one side, and bisected with “75 mg” on the opposite side. _Rimadyl Chewable Tablets 100 mg: _ A light brown rounded square tablet. Tablet is debossed “R” on one side, and bisected with “100 mg” on the opposite side. PHARMACODYNAMICS: The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenaseshave been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species. In an _in vitro _ study using canine cell cultures, carprofen demonstrated selective inhibition of COX-2 versus COX-1. Clinical revelence of these data has not been shown. Carprofen has also been shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and human rheuma synovial cells, indicating inhibition of acute (PMN system) and chronic (synovial cell system) inflammatory reactions. Several studies have demonstrated that carprofen has modulatory effects on both humoral and cellular immune responses. Data also indicate that carprofen inhibits the producti Lees het volledige document