Rimadyl Chewable 75 mg

Pays: Malaisie

Langue: anglais

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingrédients actifs:

CARPROFEN

Disponible depuis:

Zoetis Malaysia Sdn. Bhd.

DCI (Dénomination commune internationale):

CARPROFEN

Unités en paquet:

60 tablet Tablets

Fabriqué par:

Zoetis Inc.

Résumé des caractéristiques du produit

RIMADYL CHEWABLE TABLETS 25 MG:
Each tablet contains 25 mg of Carprofen.
RIMADYL CHEWABLE TABLETS 75 MG:
Each tablet contains 75 mg of Carprofen.
RIMADYL CHEWABLE TABLETS 100 MG:
Each tablet contains 100 mg of Carprofen.
PRODUCT DESCRIPTION:
_Rimadyl Chewable Tablets 25 mg: _
A light brown rounded square tablet. Tablet is debossed “R” on one
side, and bisected with “25 mg” on the opposite side.
_Rimadyl Chewable Tablets 75 mg: _
A light brown rounded square tablet. Tablet is debossed “R” on one
side, and bisected with “75 mg” on the opposite side.
_Rimadyl Chewable Tablets 100 mg: _
A light brown rounded square tablet. Tablet is debossed “R” on one
side, and bisected with “100 mg” on the opposite side.
PHARMACODYNAMICS:
The mechanism of action of carprofen, like that of other NSAIDs, is
believed to be associated with the inhibition of cyclooxygenase
activity. Two unique cyclooxygenaseshave been
described in mammals. The constitutive cyclooxygenase, COX-1,
synthesizes prostaglandins necessary for normal gastrointestinal and
renal function. The inducible cyclooxygenase, COX-2, generates
prostaglandins involved in inflammation. Inhibition of COX-1 is
thought to be associated with gastrointestinal and renal toxicity
while inhibition of COX-2 provides anti-inflammatory activity. The
specificity of a particular NSAID for COX-2 versus COX-1 may vary from
species to species. In an
_in vitro _
study using canine cell cultures, carprofen demonstrated selective
inhibition of COX-2 versus
COX-1. Clinical revelence of these data has not been shown. Carprofen
has also been shown to inhibit the release of several prostaglandins
in two inflammatory cell systems: rat polymorphonuclear
leukocytes (PMN) and human rheuma synovial cells, indicating
inhibition of acute (PMN system) and chronic (synovial cell system)
inflammatory reactions. Several studies have demonstrated that
carprofen has modulatory effects on both humoral and cellular immune
responses. Data also indicate that carprofen inhibits the producti