Land: Maleisië
Taal: Engels
Bron: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
IBUPROFEN
RB (HEALTH) MALAYSIA SDN BHD
IBUPROFEN
12 Capsules; 10 Capsules
Patheon Softgels B.V.
_Consumer Medication Information Leaflet (RiMUP)_ NUROFEN EXPRESS LIQUID CAPSULES Ibuprofen (200mg, 400mg) WHAT IS IN THIS LEAFLET: 1. What Nurofen Express Liquid Capsules is used for 2. How Nurofen Express Liquid Capsules works 3. Before you use Nurofen Express Liquid Capsules 4. How to use Nurofen Express Liquid Capsules 5. While you are using it 6. Side effects 7. Storage and Disposal of Nurofen Express Liquid Capsules 8. Product Description 9. Manufacturer and Product Registration Holder. 10. Date of revision WHAT NUROFEN EXPRESS LIQUID CAPSULES IS USED FOR relief of pain such as headache, dental pain, period pain, rheumatic pain, muscular pain and backache. They also relieve fever such as fever associated with cold & flu. HOW NUROFEN EXPRESS LIQUID CAPSULES WORKS The active ingredient (which makes the medicine work) is Ibuprofen. It belongs to a group of medicines know as non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs provide relief by changing the body’s response to pain, swelling and high temperature. BEFORE YOU USE NUROFEN EXPRESS LIQUID CAPSULES _-When you must not use it:_ Do not take Nurofen Express Liquid Capsules if you: • Are allergic to ibuprofen or any of the other ingredients or to aspirin or other painkillers • Have had a worsening of asthma, skin rash, itchy runny nose or facial swelling when previously taking ibuprofen, aspirin or similar medicines • Have (or have had two or more episodes of) a stomach ulcer, perforation or bleeding • Have had gastrointestinal bleeding or perforation when previously taking NSAIDs (non-steroidal anti- inflammatory drugs) • Have severe liver or kidney problems • Have heart problems, high blood pressure or blood coagulation disorders • Are in the last 3 months of pregnancy _-Before you start to use it_ Check with your pharmacist or your doctor before taking this product if you: • Have or have had asthma, diabetes, high cholesterol, high blood pressure, a stroke, heart, liver, kidney or bowel problems. • Have a history of gastrointestin Lees het volledige document
NUROFEN EXPRESS LIQUID CAPSULES Ibuprofen 200mg, 400mg Date of text revision: April 2022 PRODUCT DESCRIPTION Red, oval shaped transparent soft gelatin capsule with a Nurofen logo printed in white. PHARMACODYNAMIC Pharmacotherapeutic group: Anti-inflammatory and antirheumatic products, non-steroids; propionic acid derivative. ATC Code: M01A E01 Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that in the conventional animal-experiment inflammation models has proven to be effective via prostaglandin-synthesis inhibition. In humans, ibuprofen reduces inflammatory-related pain, swellings and fever. Furthermore, ibuprofen reversibly inhibits ADP-and collagen-induced platelet aggregation. Experimental data suggests that ibuprofen may inhibit the effect of low dose aspirin on platelet aggregation when they are dosed concomitantly. In one study, when a single dose of ibuprofen 400mg was taken within 8 h before or within 30 min after immediate release dosing (81 mg), a decreased effect of ASA on the formation of thromboxane of platelet aggregation occurred. Although there are uncertainties regarding extrapolation of these date to the clinical situation, the possibility that regular, long-term use of ibuprofen may reduce the cardioprotective effect of low-dose acetylsalicylic acid cannot be excluded. No clinically relevant effect is considered to be likely for occasional ibuprofen use. PHARMACOKINETIC On oral application, ibuprofen is partly absorbed in the stomach and then completely in the small intestine. Following hepatic metabolisation (hydroxylation, carboxylation), the pharmacologically inactive metabolites are completely eliminated, mainly renally (90 %), but also with the bile. The elimination half-life in healthy individuals and those with liver and kidney diseases is 1.8 - 3.5 hours, plasma-protein binding about 99 %. Peak plasma levels following oral administration of a normal-release pharmaceutical form (tablet) are reached after 1-2 hours. However, ibuprofen is absorbed more rapidly from the gastroi Lees het volledige document