Nurofen Express 200mg Liquid Capsules

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

IBUPROFEN

Boleh didapati daripada:

RB (HEALTH) MALAYSIA SDN BHD

INN (Nama Antarabangsa):

IBUPROFEN

Unit dalam pakej:

12 Capsules; 10 Capsules

Dikeluarkan oleh:

Patheon Softgels B.V.

Risalah maklumat

_Consumer Medication Information Leaflet (RiMUP)_
NUROFEN EXPRESS LIQUID CAPSULES
Ibuprofen (200mg, 400mg)
WHAT IS IN THIS LEAFLET:
1.
What
Nurofen
Express
Liquid
Capsules is used for
2.
How
Nurofen
Express
Liquid
Capsules works
3.
Before
you
use
Nurofen
Express
Liquid Capsules
4.
How to use Nurofen Express Liquid
Capsules
5.
While you are using it
6.
Side effects
7.
Storage
and
Disposal
of
Nurofen
Express Liquid Capsules
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder.
10. Date of revision
WHAT
NUROFEN
EXPRESS
LIQUID
CAPSULES IS USED FOR
relief of pain such
as headache, dental pain, period pain,
rheumatic
pain,
muscular
pain
and
backache. They also relieve fever such
as fever associated with cold & flu.
HOW
NUROFEN
EXPRESS
LIQUID
CAPSULES WORKS
The active ingredient (which makes the
medicine
work)
is
Ibuprofen.
It
belongs to a group of medicines know
as
non-steroidal
anti-inflammatory
drugs (NSAIDs).
NSAIDs provide relief by changing the
body’s response to pain, swelling and
high temperature.
BEFORE
YOU
USE
NUROFEN
EXPRESS
LIQUID CAPSULES
_-When you must not use it:_
Do not take Nurofen Express Liquid
Capsules if you:
•
Are allergic to ibuprofen or any of
the other ingredients or to aspirin or
other painkillers
•
Have
had
a
worsening
of
asthma,
skin rash, itchy runny nose or facial
swelling
when
previously
taking
ibuprofen,
aspirin
or
similar
medicines
•
Have
(or
have
had
two
or
more
episodes
of)
a
stomach
ulcer,
perforation or bleeding
•
Have had gastrointestinal bleeding or
perforation
when
previously
taking
NSAIDs
(non-steroidal
anti-
inflammatory drugs)
•
Have severe liver or kidney problems
•
Have
heart
problems,
high
blood
pressure
or
blood
coagulation
disorders
•
Are in the last 3 months of pregnancy
_-Before you start to use it_
Check
with
your
pharmacist
or
your
doctor before taking this product if you:
•
Have or have had asthma, diabetes,
high cholesterol, high blood pressure,
a stroke, heart, liver, kidney or bowel
problems.
•
Have
a
history
of
gastrointestin

Ciri produk

NUROFEN EXPRESS LIQUID CAPSULES
Ibuprofen 200mg, 400mg
Date of text revision: April 2022
PRODUCT DESCRIPTION
Red, oval shaped transparent soft gelatin capsule with a Nurofen logo
printed in white.
PHARMACODYNAMIC
Pharmacotherapeutic group: Anti-inflammatory and antirheumatic
products, non-steroids; propionic acid derivative.
ATC Code: M01A E01
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that in the
conventional animal-experiment inflammation models has proven to
be effective via prostaglandin-synthesis inhibition. In humans,
ibuprofen reduces inflammatory-related pain, swellings and fever.
Furthermore,
ibuprofen reversibly inhibits ADP-and collagen-induced platelet
aggregation. Experimental data suggests that ibuprofen may inhibit the
effect
of low dose aspirin on platelet aggregation when they are dosed
concomitantly. In one study, when a single dose of ibuprofen 400mg was
taken within 8 h before or within 30 min after immediate release
dosing (81 mg), a decreased effect of ASA on the formation of
thromboxane
of platelet aggregation occurred. Although there are uncertainties
regarding extrapolation of these date to the clinical situation, the
possibility that
regular, long-term use of ibuprofen may reduce the cardioprotective
effect of low-dose acetylsalicylic acid cannot be excluded. No
clinically
relevant effect is considered to be
likely for occasional ibuprofen use.
PHARMACOKINETIC
On oral application, ibuprofen is partly absorbed in the stomach and
then completely in the small intestine.
Following hepatic metabolisation (hydroxylation, carboxylation), the
pharmacologically inactive metabolites are completely eliminated,
mainly renally (90 %), but also with the bile. The elimination
half-life in healthy individuals and those with liver and kidney
diseases is 1.8 -
3.5
hours, plasma-protein binding about 99 %.
Peak plasma levels following oral administration of a normal-release
pharmaceutical form (tablet) are reached after 1-2 hours. However,
ibuprofen is absorbed more rapidly from the gastroi