Land: Indonesië
Taal: Indonesisch
Bron: Badan Pengawas Obat dan Makanan RI - Indonesian Food and Drug Supervisory Agency
IVERMECTIN
INDOFARMA - Indonesia
IVERMECTIN
12 MG
TABLET
DUS, 1 BOTOL @ 20 TABLET
INDOFARMA - Indonesia
2021-06-20
Nama _artwork_ BROSUR IVERMECTIN Ukuran brosur 75 x 220 mm Bahan brosur HVS 60 g/m² Warna teks Hitam Logo Indofarma Hitam Kode brosur - Edisi - Dibuat oleh : Gilang.H. IVERMECTIN TABLET 12 MG COMPOSITION Each tablet contains ivermectin 12 mg. PHARMACOLOGY PHARMACOKINETICS Following oral administration of Ivermectin, plasma concentrations are approximately proportional to the dose. Ivermectin is metabolized in the liver, and Ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine. The plasma half-life of Ivermectin in man is approximately 18 hours following oral administration. Ivermectin is primarily metabolized by CYP3A4. CYP2D6 and CYP2E1 were also shown to be involved in the metabolism of Ivermectin but to a significantly lower extent compared to CYP3A4. Concentrations of Ivermectin do not significantly inhibit the metabolizing activities of CYP3A4, CYP2D6, CYP2C9, CYP1A2, and CYP2E1. MICROBIOLOGY Ivermectin is a member of the avermectin class of broad-spectrum antiparasitic agents which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The selective activity of compounds of this class is attributable to the facts that some mammals do not have glutamate-gated chloride channels and that the avermectins have a low affinity for mammalian ligand-gated chloride channels. In addition, Ivermectin does not readily cross the blood-brain barrier in humans. INDICATIONS Ivermectin is indicated for the treatment of the following infect Lees het volledige document