IVERMECTIN

Maa: Indonesia

Kieli: indonesia

Lähde: Badan Pengawas Obat dan Makanan RI - Indonesian Food and Drug Supervisory Agency

Aktiivinen ainesosa:

IVERMECTIN

Saatavilla:

INDOFARMA - Indonesia

INN (Kansainvälinen yleisnimi):

IVERMECTIN

Annos:

12 MG

Lääkemuoto:

TABLET

Kpl paketissa:

DUS, 1 BOTOL @ 20 TABLET

Valmistaja:

INDOFARMA - Indonesia

Valtuutus päivämäärä:

2021-06-20

Valmisteyhteenveto

Nama _artwork_
BROSUR IVERMECTIN
Ukuran brosur
75 x 220 mm
Bahan brosur
HVS 60 g/m²
Warna teks
Hitam
Logo Indofarma
Hitam
Kode brosur
-
Edisi
-
Dibuat oleh :
Gilang.H.
IVERMECTIN
TABLET 12 MG
COMPOSITION
Each tablet contains ivermectin 12 mg.
PHARMACOLOGY
PHARMACOKINETICS
Following oral administration of Ivermectin, plasma concentrations are
approximately proportional to the dose. Ivermectin is metabolized in
the
liver, and Ivermectin and/or its metabolites are excreted almost
exclusively
in the feces over an estimated 12 days, with less than 1% of the
administered dose excreted in the urine. The plasma half-life of
Ivermectin
in man is approximately 18 hours following oral administration.
Ivermectin is primarily metabolized by CYP3A4. CYP2D6 and CYP2E1
were also shown to be involved in the metabolism of Ivermectin but to
a
significantly
lower
extent
compared
to
CYP3A4.
Concentrations
of
Ivermectin
do
not
significantly
inhibit
the
metabolizing
activities
of
CYP3A4, CYP2D6, CYP2C9, CYP1A2, and CYP2E1.
MICROBIOLOGY
Ivermectin is a member of the avermectin class of broad-spectrum
antiparasitic agents which have a unique mode of action. Compounds of
the class bind selectively and with high affinity to glutamate-gated
chloride
ion channels which occur in invertebrate nerve and muscle cells. This
leads to an increase in the permeability of the cell membrane to
chloride
ions with hyperpolarization of the nerve or muscle cell, resulting in
paralysis and death of the parasite. Compounds of this class may also
interact with other ligand-gated chloride channels, such as those
gated by
the neurotransmitter gamma-aminobutyric acid (GABA).
The selective activity of compounds of this class is attributable to
the facts
that some mammals do not have glutamate-gated chloride channels and
that the avermectins have a low affinity for mammalian ligand-gated
chloride channels. In addition, Ivermectin does not readily cross the
blood-brain barrier in humans.
INDICATIONS
Ivermectin is indicated for the treatment of the following infect