Land: Nieuw-Zeeland
Taal: Engels
Bron: Medsafe (Medicines Safety Authority)
Aciclovir 800mg
Global Pharmaceuticals Limited
Aciclovir 800 mg
800 mg
Tablet
Active: Aciclovir 800mg Excipient: Colloidal silicon dioxide Magnesium stearate Microcrystalline cellulose Povidone Sodium starch glycolate
Blister pack, Al/PVC (7x5), 35 tablets
Prescription
Prescription
Lek Pharmaceuticals d.d.
Package - Contents - Shelf Life: Blister pack, Al/PVC (7x5) - 35 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 35 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 50 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 100 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 250 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 500 tablets - 48 months from date of manufacture stored at or below 25°C
1998-08-24
Medsafe Logo INFORMATION FOR HEALTH PROFESSIONALS Home | Consumers | Health Professionals | Regulatory | Other | Hot Topics | Search Data Sheet GLOBAL ACYCLOVIR Acyclovir 400mg and 800mg tablets Presentation GLOBAL ACYCLOVIR 400mg tablets are white, oval biconvex tablets identified ACY400 on one side. Each tablet contains 400mg acyclovir and typically weighs 525mg. GLOBAL ACYCLOVIR 800mg tablets are white, oval biconvex tablets identified ACY800 on one side and a breakline on the other. Each tablet contains 800mg acyclovir and typically weighs 1050mg. Uses Actions Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against human herpes viruses, varicella-zoster virus, Epstein-Barr virus and to a lesser extent cytomegalovirus. Acyclovir has an antiviral effect on herpes simplex viruses and varicella zoster virus resulting from its interference with DNA synthesis leading to inhibition of virus replication. The exact mechanism of acyclovir action in other susceptible viruses has not been fully elucidated. Acyclovir triphosphate is the pharmacologically active metabolite of the drug. The initial phosphorylation of acyclovir to acyclovir monophosphate is catalysed by virus-induced thymidine kinase. Thus selective activation of the drug is achieved principally in infected cells. Further phosphorylation to acyclovir diphosphate is catalysed via cellular guanylate kinase and then phosphorylation to acyclovir triphosphate is catalysed via other intracellular enzymes (phosphoglycerate kinase, pyruvate kinase, phosphoenolpyruvate carboxykinase). The extent of formation of acyclovir monophosphate, diphosphate and triphosphate is directly related to the concentration of acyclovir in the cellular culture medium. In vitro studies indicate tha Lees het volledige document