Global Acyclovir

Riik: Uus-Meremaa

keel: inglise

Allikas: Medsafe (Medicines Safety Authority)

Toimeaine:

Aciclovir 800mg

Saadav alates:

Global Pharmaceuticals Limited

INN (Rahvusvaheline Nimetus):

Aciclovir 800 mg

Annus:

800 mg

Ravimvorm:

Tablet

Koostis:

Active: Aciclovir 800mg Excipient: Colloidal silicon dioxide Magnesium stearate Microcrystalline cellulose Povidone Sodium starch glycolate

Ühikuid pakis:

Blister pack, Al/PVC (7x5), 35 tablets

Klass:

Prescription

Retsepti tüüp:

Prescription

Valmistatud:

Lek Pharmaceuticals d.d.

Toote kokkuvõte:

Package - Contents - Shelf Life: Blister pack, Al/PVC (7x5) - 35 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 35 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 50 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 100 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 250 tablets - 48 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE, pp cap - 500 tablets - 48 months from date of manufacture stored at or below 25°C

Loa andmise kuupäev:

1998-08-24

Toote omadused

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Data Sheet
GLOBAL ACYCLOVIR
Acyclovir 400mg and 800mg tablets
Presentation
GLOBAL ACYCLOVIR 400mg tablets are white, oval biconvex tablets identified ACY400 on one
side. Each tablet contains 400mg acyclovir and typically weighs 525mg.
GLOBAL ACYCLOVIR 800mg tablets are white, oval biconvex tablets identified ACY800 on one
side and a breakline on the other. Each tablet contains 800mg acyclovir and typically weighs 1050mg.
Uses
Actions
Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against
human herpes viruses, varicella-zoster virus, Epstein-Barr virus and to a lesser extent cytomegalovirus.
Acyclovir has an antiviral effect on herpes simplex viruses and varicella zoster virus resulting from its
interference with DNA synthesis leading to inhibition of virus replication. The exact mechanism of
acyclovir action in other susceptible viruses has not been fully elucidated.
Acyclovir triphosphate is the pharmacologically active metabolite of the drug. The initial
phosphorylation of acyclovir to acyclovir monophosphate is catalysed by virus-induced thymidine
kinase. Thus selective activation of the drug is achieved principally in infected cells. Further
phosphorylation to acyclovir diphosphate is catalysed via cellular guanylate kinase and then
phosphorylation to acyclovir triphosphate is catalysed via other intracellular enzymes (phosphoglycerate
kinase, pyruvate kinase, phosphoenolpyruvate carboxykinase). The extent of formation of acyclovir
monophosphate, diphosphate and triphosphate is directly related to the concentration of acyclovir in the
cellular culture medium. In vitro studies indicate tha