Land: Maleisië
Taal: Engels
Bron: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ERYTHROMYCIN STEARATE
DUOPHARMA (M) SDN. BHD.
ERYTHROMYCIN STEARATE
100 Tablet Tablets; 1000 Tablet Tablets; 500 Tablet Tablets; 10 Tablet Tablets
DUOPHARMA MANUFACTURING (BANGI) SDN BHD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ _ _ ERYSON TABLET Erythromycin (250mg) _ _ 1 WHAT IS IN THIS LEAFLET 1. What ERYSON TABLET is used for 2. How ERYSON TABLET works 3. Before you use ERYSON TABLET 4. How to use ERYSON TABLET 5. While you are using ERYSON TABLET 6. Side effects 7. Storage and disposal of ERYSON TABLET 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT ERYSON TABLET IS USED FOR ERYSON TABLET is used to treat and prevent infections such as bronchitis, enteritis, venereal diseases, diphtheria, Legionella infections, pertussis, pneumonia, sinusitis, prophylaxis of surgical infections, inflammation in tissue layer of heart, pharyngitis, perinatal streptococcal infections, rheumatic fever, alternative to tetracyclines in Lyme disease, chlamydial & rickettsial infections and severe acne. HOW ERYSON TABLET WORKS ERYSON TABLET consists of active substance Erythromycin. Erythromycin _ _ is an antibiotic that belongs to the group of medicines called macrolides. These mediciens work by killing or stopping the growth of bacteria, which cause infections. BEFORE YOU USE ERYSON TABLET _-_ _ _ _When you must not use it _ Do not use ERYSON TABLET if you have had any of the following medical conditions unless advised otherwise by your doctor: If you are hypersensitive to, or have had an allergic reaction to Eryhtromycin, other Macrolide or any other ingredients in this medicine. If you have previously developed liver problem while receiving Erythromycin If you have history of developed vardiac arrhythmias (irregulat heart beat) after receiving Erythromycin If you have hearing loss, kidney or liver problem. If you are elderly _-_ _ _ _Before you start to use it _ Before taking ERYSON TABLET, you must tell your doctor or pharmacist if you have, or have had, any of the following conditions: Kidney problem, liver disease Irregular heart rhythm _Pregnancy _ ERYTHROMYCIN IS NOT RECOMMENDED FOR USE IN PREGNANCY. _Lactation _ ERYTHROMY Lees het volledige document
DESCRIPTION PHARMACOKINETICS INDICATIONS DOSAGE PHARMACODYNAMICS TOXICOLOGY Bronchitis, enteritis, venereal diseases, diphtheria, Legionella infections, pertussis, pneumonia, sinusitis. Prophylaxis of surgical infections, endocarditis, pharyngitis, perinatal streptococcal infections, rheumatic fever. Alternative to tetracyclines in Lyme disease, chlamydial & rickettsial infections, severe acne. Erythromycin is thought to penetrate the bacterial cell membrane and to reversibly bind to the 50S subunit of bacterial ribosomes; it does not directly inhibit peptide formation, but rather inhibits the translocation of peptides from the acceptor site on the ribosome to the donor site, inhibiting subsequent protein synthesis and hence cell growth. Erythromycin is effective only against actively dividing organisms. Because of the ready penetration of macrolides into white blood cells and macrophages there has been some interest in their potential synergy with host defence mechanisms in vivo. Its actions are increased at moderately alkaline pH (up to about 8.5), particularly in Gram-negative species, probably because of the improved cellular penetration of the nonionised form of the drug. Erythromycin base is unstable in gastric acid, and absorption is therefore variable and unreliable. In consequence, the base is usually administered in film- or enteric-coated preparations, or one of the more acid-stable salts or esters is employed. Food may reduce the absorption of the base or the stearate (as in Eryson 250 Tablet ), although this depends to some extent on the formulation. The ethylsuccinate ester (as in Eryson Granules) is generally more reliably and quickly absorbed and their absorption is little better when taken with meals. Peak plasma concentrations generally occur between 1-4 hours after administration, and have been reported to range between 0.3-0.5 mcg/mL after 250 mg of erythromycin stearate or 500 mg of ethylsuccinate. Fifty-five percent of ethylsuccinate is present as the active base the rest being present as th Lees het volledige document