ERYSON TABLET 250

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ERYTHROMYCIN STEARATE

Boleh didapati daripada:

DUOPHARMA (M) SDN. BHD.

INN (Nama Antarabangsa):

ERYTHROMYCIN STEARATE

Unit dalam pakej:

100 Tablet Tablets; 1000 Tablet Tablets; 500 Tablet Tablets; 10 Tablet Tablets

Dikeluarkan oleh:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
_ _
ERYSON TABLET
Erythromycin (250mg)
_ _
1
WHAT IS IN THIS LEAFLET
1.
What ERYSON TABLET is
used for
2.
How
ERYSON
TABLET
works
3.
Before you use ERYSON
TABLET
4.
How
to
use
ERYSON
TABLET
5.
While
you
are
using
ERYSON TABLET
6.
Side effects
7.
Storage
and
disposal
of
ERYSON TABLET
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT ERYSON TABLET IS
USED FOR
ERYSON TABLET is used to
treat
and
prevent
infections
such as bronchitis, enteritis,
venereal
diseases,
diphtheria,
Legionella infections, pertussis,
pneumonia,
sinusitis,
prophylaxis
of
surgical
infections,
inflammation
in
tissue
layer
of
heart,
pharyngitis,
perinatal
streptococcal
infections,
rheumatic fever, alternative to
tetracyclines in Lyme disease,
chlamydial
&
rickettsial
infections and severe acne.
HOW
ERYSON
TABLET
WORKS
ERYSON TABLET consists of
active substance Erythromycin.
Erythromycin
_ _
is
an
antibiotic
that
belongs
to
the group of
medicines
called
macrolides.
These
mediciens
work
by
killing or stopping the growth
of
bacteria,
which
cause
infections.
BEFORE
YOU
USE
ERYSON
TABLET
_-_
_ _
_When you must not use it _
Do not use ERYSON TABLET
if
you
have
had
any
of
the
following
medical
conditions
unless
advised
otherwise
by
your doctor:

If you are hypersensitive to,
or
have
had
an
allergic
reaction
to
Eryhtromycin,
other Macrolide or any other
ingredients in this medicine.

If
you
have
previously
developed
liver
problem
while
receiving
Erythromycin

If
you
have
history
of
developed
vardiac
arrhythmias (irregulat heart
beat)
after
receiving
Erythromycin

If
you
have
hearing
loss,
kidney or liver problem.

If you are elderly
_-_
_ _
_Before you start to use it _
Before
taking
ERYSON
TABLET, you must tell your
doctor
or
pharmacist
if
you
have, or have had, any of the
following conditions:

Kidney
problem,
liver
disease

Irregular heart rhythm
_Pregnancy _
ERYTHROMYCIN
IS
NOT
RECOMMENDED
FOR
USE
IN
PREGNANCY.
_Lactation _
ERYTHROMY

Ciri produk

DESCRIPTION
PHARMACOKINETICS
INDICATIONS
DOSAGE
PHARMACODYNAMICS
TOXICOLOGY
Bronchitis, enteritis, venereal diseases, diphtheria, Legionella
infections, pertussis,
pneumonia, sinusitis. Prophylaxis of surgical infections,
endocarditis, pharyngitis,
perinatal streptococcal infections, rheumatic fever. Alternative to
tetracyclines in Lyme
disease, chlamydial & rickettsial infections, severe acne.
Erythromycin is thought to penetrate the bacterial cell membrane and
to reversibly
bind to the 50S subunit of bacterial ribosomes; it does not directly
inhibit peptide
formation, but rather inhibits the translocation of peptides from the
acceptor site on
the ribosome to the donor site, inhibiting subsequent protein
synthesis and hence cell
growth. Erythromycin is effective only against actively dividing
organisms. Because of
the ready penetration of macrolides into white blood cells and
macrophages there has
been some interest in their potential synergy with host defence
mechanisms in vivo. Its
actions are increased at moderately alkaline pH (up to about 8.5),
particularly in
Gram-negative species, probably because of the improved cellular
penetration of the
nonionised form of the drug.
Erythromycin base is unstable in gastric acid, and absorption is
therefore variable and
unreliable. In consequence, the base is usually administered in film-
or enteric-coated
preparations, or one of the more acid-stable salts or esters is
employed. Food may
reduce the absorption of the base or the stearate (as in Eryson 250
Tablet ), although
this depends to some extent on the formulation.
The ethylsuccinate ester (as in Eryson Granules) is generally more
reliably and quickly
absorbed and their absorption is little better when taken with meals.
Peak plasma
concentrations generally occur between 1-4 hours after administration,
and have been
reported to range between 0.3-0.5 mcg/mL after 250 mg of erythromycin
stearate or
500 mg of ethylsuccinate. Fifty-five percent of ethylsuccinate is
present as the active
base the rest being present as th